普拉克索治疗不宁腿综合征疗效的系统评价

发布时间：2018-11-26 08:21

【摘要】：目的系统评价普拉克索治疗不宁腿综合征(RLS)的临床疗效和安全性。方法检索1970年1月至2013年4月相关期刊论文(CNKI)、中国生物医学文献数据库(CBM)、美国国立医学生物信息中心Pub Med数据库(Pub Med)、Cochrane图书馆临床对照试验资料库(CENTRAL)、荷兰医学文摘数据库(Embase)关于普拉克索治疗RLS随机对照研究的文献。按照纳入和排除标准选择文献,并采用STATA12.0软件进行Meta分析。结果共纳入8个随机对照试验,合计2 218例RLS患者,其中试验组1 333例,对照组885例,其中4个研究方法学质量为A级,另外4个为B级。Meta分析结果显示:1RLS改变量(IRLS评分),普拉克索组明显优于安慰剂组〔SMD=-2.43,95%CI(-4.40,-0.46),P0.05〕;2反应率临床总体印改善量表评分〔(CGI-I)评分〕,普拉克索组反应率优于安慰剂组〔RR=1.35,95%CI(1.23,1.48),P0.05〕;3安全性分析(不良反应事件),普拉克索组低于安慰剂组〔RR=1.13,95%CI(1.03,1.24),P0.05〕。结论普拉克索能有效改善RLS患者的症状,耐受性较好。但受到纳入文献数量限制,以上结论尚需更多高质量的临床试验进一步证实。
[Abstract]:Objective to evaluate the clinical efficacy and safety of Praxol in the treatment of restless leg syndrome (RLS). Methods from January 1970 to April 2013, the Chinese Journal Full-text Database (CNKI), Chinese Biomedical Literature Database (CBM), Pub Med Database (Pub Med),) of the National Medical Information Center of the United States of America, was searched. Cochrane Library Clinical controlled trial Database (CENTRAL), Netherlands Medical Abstracts Database (Embase) literature on RLS randomized controlled study of Platexol therapy. Literature was selected according to inclusion and exclusion criteria, and Meta analysis was carried out with STATA12.0 software. Results A total of 2 218 patients with RLS were enrolled in 8 randomized controlled trials, including 1 333 cases in the trial group and 885 cases in the control group. The other 4 were B grade. Meta analysis showed that the changes of 1RLS (IRLS score) were significantly better in the Platexol group than in the placebo group (SMD=-2.43,95%CI (-4.40) -0.46, P0.05). (2) the response rate of the Prackesol group was better than that of the placebo group (RR=1.35,95%CI (1.23 卤1.48), P0.05). 3 Safety analysis (adverse events), the Praxol group was lower than the placebo group (RR=1.13,95%CI (1.03 卤1.24), P0.05). Conclusion Praxol can effectively improve the symptoms of RLS patients and has good tolerance. However, limited by the number of literature included, the above conclusions need to be further confirmed by high-quality clinical trials.
【作者单位】：南昌大学附属九江医院神经内科;
【分类号】：R740

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