ICU耐美罗培南铜绿假单胞菌感染的治疗分析

发布时间：2018-12-21 18:57

【摘要】：目的探讨ICU耐美罗培南铜绿假单胞菌感染的危险因素,以期采取最佳治疗对策控制感染。方法选择2011年5月-2013年6月医院感染耐美罗培南铜绿假单胞菌35例患者为研究对象,作为研究组,选取同期未感染耐美罗培南铜绿假单胞菌36例患者作为对照组,采用多因素分析感染的相关危险因素,对比治疗前后研究组在白细胞计数、中性粒细胞百分比、体温、C-反应蛋白等炎症指标的变化情况;使用SPSS16.0软件对数据进行统计分析。结果机械通气时间1周、入住ICU时间1周、经验性使用碳青霉烯类抗菌药物是ICU住院患者感染耐美罗培南铜绿假单胞菌的相关危险因素(P0.05);而机械通气时间、入住ICU时间、经验性使用碳青霉烯类抗菌药物是ICU感染耐美罗培南铜绿假单胞菌独立危险因素(P0.01);研究组患者治疗前白细胞、中性粒细胞、体温、C-反应蛋白分别为(14.73±5.62)×109/L、(81.42±5.68)%、(39.11±0.34)℃、(67.35±36.36)mg/L,治疗后分别为(7.83±1.23)×109/L、(58.95±4.23)%、(36.72±0.25)℃、(6.78±3.56)mg/L,治疗前后比较差异有统计学意义(P0.05)。结论早期细菌学检查确诊致病菌,减少经验性碳青霉烯类抗菌药物使用,加强ICU消毒隔离措施,减少机械通气时间,可有效降低ICU耐美罗培南铜绿假单胞菌感染。
[Abstract]:Objective to investigate the risk factors of ICU-resistant Pseudomonas aeruginosa infection in order to control the infection. Methods from May 2011 to June 2013, 35 patients with pseudomonas aeruginosa resistant to meropenem were selected as the study group and 36 patients with pseudomonas aeruginosa resistant to meropenem as the control group. The risk factors of infection were analyzed by multivariate analysis, and the changes of leukocyte count, percentage of neutrophils, body temperature and C-reactive protein were compared before and after treatment in the study group. Use SPSS16.0 software to carry on the statistical analysis to the data. Results the time of mechanical ventilation was 1 week, the time of staying in ICU was 1 week. The empirical use of carbapenem antibiotics was the risk factor of infection of Pseudomonas aeruginosa resistant to meropenem in ICU inpatients (P0.05). The time of mechanical ventilation, the time of staying in ICU, the empirical use of carbapenem antibiotics were the independent risk factors of ICU infection with meropenem resistant Pseudomonas aeruginosa (P0.01). Before treatment, leukocytes, neutrophils, body temperature and C-reactive protein were (14.73 卤5.62) 脳 10 ~ 9 / L, (81.42 卤5.68)%, (39.11 卤0.34) 鈩，

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