儿童沙门菌感染临床特点及耐药模式

发布时间：2019-01-02 12:41

【摘要】：目的了解儿童沙门菌感染的流行特征和耐药模式。方法分析2012年2月—2014年9月住院且粪便细菌培养出沙门菌菌株患儿的临床特点,以及沙门菌的血清型和药敏试验结果。结果从2 678例住院患儿粪便标本中检测出87株沙门菌,5—9月份共检测出64株(73.56%)。87例沙门菌阳性患儿中,男58例、女29例,其中2岁的68例(78.16%)。临床症状主要为脓血便65例(74.71%),发热72例(82.76%)。合并有轮状病毒感染10例(11.49%)。经沙门菌血清学鉴定,分别为布利丹沙门菌6株,肠炎沙门菌6株,鼠伤寒沙门菌5株,亚利桑那沙门菌3株,奥拉宁堡沙门菌2株,策维埃沙门菌2株,纽兰芝沙门菌、德比沙门菌、阿哥纳沙门菌、布伦登芦普沙门菌、埃可沙门菌各1株。药敏试验结果显示,沙门菌对头孢唑啉、头孢呋辛、庆大霉素的耐药率分别为94.25%、87.36%、87.36%,有26株(29.89%)沙门菌呈多重耐药。结论 2岁儿童沙门菌易感,男性患儿居多,主要表现为脓血便、发热,有部分合并轮状病毒感染;沙门菌血清型以布利丹沙门菌、肠炎沙门菌和鼠伤寒沙门菌多见,对多种抗生素耐药,甚至多重耐药。
[Abstract]:Objective to investigate the epidemic characteristics and drug resistance patterns of salmonella infection in children. Methods from February 2012 to September 2014, the clinical characteristics of children with Salmonella strains cultured from fecal bacteria were analyzed, and the results of serotype and drug sensitivity tests of Salmonella were also analyzed. Results Eighty-seven strains of salmonella were detected from fecal specimens of 2678 hospitalized children, 64 strains (73.56%) were detected in May and September, 58 cases were males and 29 cases were females, 68 cases were 2 years old (78.16%). The main clinical symptoms were sepsis in 65 cases (74.71%) and fever in 72 cases (82.76%). 10 cases (11.49%) were complicated with rotavirus infection. Six strains of Salmonella britanum, 6 strains of Salmonella enteritis, 5 strains of Salmonella typhimurium, 3 strains of Salmonella Arizona, 2 strains of Salmonella oxalaningii, 2 strains of Salmonella Zevier, and 2 strains of Salmonella Neulanderma were identified as Salmonella, and Salmonella. Derby Salmonella, Agona Salmonella, Brendon Rupu Salmonella, Echo Salmonella, 1 each. The results of drug sensitivity test showed that the resistance rates of Salmonella to cefazolin, cefuroxime and gentamicin were 94.25%, 87.36% and 87.36%, respectively, and 26 strains (29.89%) were multidrug resistant. Conclusion Children aged 2 years are susceptible to Salmonella, most of them are male, which are mainly characterized by purulent blood stool, fever and some rotavirus infection. The serotypes of Salmonella were Blidan Salmonella enteritis Salmonella and Salmonella typhimurium.
【作者单位】：南京医科大学附属南京儿童医院消化科;南京医科大学附属南京儿童医院微生物室;
【分类号】：R446

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