不同海拔地区健康人淋巴细胞亚群、血小板及凝血功能的改变

发布时间：2019-01-06 10:43

【摘要】：目的观察不同海拔地区健康人淋巴细胞亚群、血小板及凝血功能的改变。方法对西安(海拔400 m)、西宁(海拔2 300 m)以及兴海县(海拔4 000 m)健康体检人群进行静脉采血,测定血液中淋巴细胞亚群,血清免疫指标,血小板计数及凝血指标。结果西安组与西宁组及兴海组比较CD3~+、CD4~+、CD19~+淋巴细胞亚群均有统计学差异(P0.05),且西宁组与兴海组比较也具有统计学差异(P0.05);西安组、西宁组以及兴海组两两比较CD8~+淋巴细胞亚群均无统计学差异(P0.05);兴海组与西安组及西宁组比较CD4~+/CD8~+有统计学差异(P0.05),但西安组与西宁组比较CD4~+/CD8~+无统计学差异(P0.05);西安组与西宁组及兴海组比较Ig G、Ig M及Ig A均有统计学差异(P0.05),且西宁组与兴海组比较也具有统计学差异(P0.05)。西安组与西宁组及兴海组比较CD62p、CD63细胞亚群及血小板计数均有统计学差异(P0.05),且西宁组与兴海组比较也有统计学差异(P0.05);西安组与西宁组及兴海组比较PT、APTT、FIB及TT均有统计学差异(P0.05),且西宁组与兴海组比较也有统计学差异(P0.05)。结论随着海拔的升高,氧浓度的下降,正常人群淋巴细胞亚群CD3~+、CD4~+及CD19~+百分比逐渐下降,CD4~+/CD8~+逐渐下降,血清免疫指标逐渐升高,血小板计数逐渐下降但血小板活化百分率逐渐升高,凝血指标PT、APTT、TT逐渐延长,FIB含量逐渐下降。高海拔生活的人群为适应低氧环境机体的部分指标发生了改变。
[Abstract]:Objective to observe the changes of lymphocyte subsets, platelet and coagulation function in healthy people at different elevations. Methods Blood samples were collected from healthy people in Xi'an (400 m),) Xining (2 300m) and Xinghai County (4 000 m). The lymphocyte subsets in blood, serum immune index, platelet count and coagulation index were measured. Results the lymphocyte subsets of CD3~, CD4~ and CD19~ in Xi'an group were significantly different from those in Xining group and Xinghai group (P0.05), and there were statistical differences between Xining group and Xinghai group (P0.05). There was no significant difference in CD8~ lymphocyte subsets among Xi'an group, Xining group and Xinghai group (P0.05). There was significant difference in CD4~ / CD8~ between Xinghai group and Xi'an group and Xining group (P0.05), but there was no significant difference in CD4~ / CD8~ between Xi'an group and Xining group (P0.05). Xi'an group compared with Xining group and Xinghai group, Ig G M and Ig A were significantly different (P0.05), and Xining group and Xinghai group also had statistical difference (P0.05). In Xi'an group, Xining group and Xinghai group, CD62p,CD63 cell subsets and platelet count were significantly different (P0.05), and Xining group and Xinghai group also had statistical difference (P0.05). Compared with Xining group and Xinghai group, PT,APTT,FIB and TT in Xi'an group were statistically different (P0.05), and Xining group and Xinghai group also had statistical difference (P0.05). Conclusion with the increase of altitude and the decrease of oxygen concentration, the percentage of CD3~, CD4~ and CD19~ of lymphocyte subsets in normal population decreased gradually, CD4~ / CD8~ decreased gradually, and the serum immune index increased gradually. The platelet count decreased gradually but the percentage of platelet activation increased, the coagulation index PT,APTT,TT prolonged and the content of FIB decreased gradually. People living at high altitudes have changed some of their indicators to adapt to hypoxic conditions.
【作者单位】：青海省人民医院;
【分类号】：R446.11

【相似文献】