双调制多波长旋光法检测人工前房内葡萄糖的浓度
发布时间：2019-02-26 19:36
【摘要】：光学旋光法是一种无创血糖检测技术,通过测量眼前房水内葡萄糖浓度来确定体内血糖浓度水平。人眼运动引起的实时变化的双折射是实现旋光法无创血糖测量的主要限制因素之一。设计了实时、闭环、双调制多波长偏振系统来测量人工前房内的葡萄糖浓度,人工前房由离体角膜固定在人工眼房上构成。采用眼耦合装置使光直线穿过眼前房从而避免了空气与角膜之间折射率不匹配引起的光线弯曲。存在运动引起的双折射时,采用双波长旋光系统测量眼模型内的葡萄糖浓度,两次预测葡萄糖浓度的标准差分别为18.9mg/dL和15.2mg/dL,表明该系统具有降低活体角膜实变双折射的潜力,有利于实现与血糖浓度相关的眼前房水内葡萄糖浓度的精确测量。
[Abstract]:Optical rotation is a non-invasive blood glucose detection technique. Glucose concentration in aqueous humor can be determined by measuring glucose concentration in aqueous humor. Birefringence of real-time changes caused by human eye movement is one of the main limiting factors for noninvasive measurement of blood glucose by optical rotation. A real-time, closed-loop, dual-modulation multi-wavelength polarization system was designed to measure glucose concentration in the artificial anterior chamber, which was composed of an isolated cornea fixed on the artificial chamber. The eye coupling device is used to make the light straight through the anterior chamber so as to avoid the bending of light caused by the refractive index mismatch between the air and the cornea. In the presence of birefringence caused by motion, the glucose concentration in the eye model was measured by dual-wavelength optical rotation system. The standard deviation for the twice prediction of glucose concentration was 18.9mg/dL and 15.2mg / kg 路dL, respectively. It is suggested that the system has the potential to reduce birefringence of corneal consolidation in vivo, which is beneficial to the accurate measurement of glucose concentration in aqueous humor related to blood glucose concentration.
【作者单位】： 电子科技大学光电信息学院;德克萨斯州农工大学生物医学工程学院光学生物传感实验室;
【分类号】：O439;R446.1
本文编号：2431084
[Abstract]:Optical rotation is a non-invasive blood glucose detection technique. Glucose concentration in aqueous humor can be determined by measuring glucose concentration in aqueous humor. Birefringence of real-time changes caused by human eye movement is one of the main limiting factors for noninvasive measurement of blood glucose by optical rotation. A real-time, closed-loop, dual-modulation multi-wavelength polarization system was designed to measure glucose concentration in the artificial anterior chamber, which was composed of an isolated cornea fixed on the artificial chamber. The eye coupling device is used to make the light straight through the anterior chamber so as to avoid the bending of light caused by the refractive index mismatch between the air and the cornea. In the presence of birefringence caused by motion, the glucose concentration in the eye model was measured by dual-wavelength optical rotation system. The standard deviation for the twice prediction of glucose concentration was 18.9mg/dL and 15.2mg / kg 路dL, respectively. It is suggested that the system has the potential to reduce birefringence of corneal consolidation in vivo, which is beneficial to the accurate measurement of glucose concentration in aqueous humor related to blood glucose concentration.
【作者单位】： 电子科技大学光电信息学院;德克萨斯州农工大学生物医学工程学院光学生物传感实验室;
【分类号】：O439;R446.1
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