住院患者感染金黄色葡萄球菌分布与耐药性回顾性断面研究

发布时间：2019-04-11 09:38

【摘要】：目的了解住院患者感染金黄色葡萄球菌(SAU)分布与耐药性,为深入研究金黄色葡萄球菌的致病性和耐药机制奠定基础。方法对2012年1月-2014年12月住院患者98 127份来自血液、胸腹水、尿液、感染灶分泌物/脓肿引流物、术后引流液、肺泡灌洗液(BALF)、鼻咽拭子和痰液等标本进行回顾性分析,分析感染SAU的分布及其对常用抗菌药物耐药趋势。结果 2012年1月-2014年12月住院患者共送检各类标本98 127份,标本检测阳性20 132份,阳性率20.52%;共检出率SAU 1 053株,检出率为5.23%;464株来源于合格下呼吸道标本,208株来源于感染灶分泌物/脓肿穿刺/引流物,60株来源于鼻咽拭子,分别占44.07%、19.75%、5.70%;SAU主要分布在呼吸科、儿科及ICU,分布率分别为17.19%、15.95%、11.30%;SAU对头孢曲松、氨苄西林/舒巴坦、四环素耐药率波动显示,差异有统计学意义(P0.05),对青霉素G、苯唑西林、阿莫西林/克拉维酸钾、头孢唑林等耐药率变化,差异无统计学意义,未发现耐万古霉素、利奈唑胺菌株;3年耐甲氧西林金黄色葡萄球菌(MRSA)检出率分别为43.30%、38.10%、37.10%,差异无统计学意义。结论 SAU在住院患者各系统感染中均占有重要地位;SAU对不同抗菌药物的耐药率不同。
[Abstract]:Objective to investigate the (SAU) distribution and drug resistance of Staphylococcus aureus in hospitalized patients, and to lay a foundation for further study on the pathogenicity and drug resistance mechanism of Staphylococcus aureus. Methods from January 2012 to December 2014, 98 127 samples from blood, pleural and ascites, urine, secretions / abscess drainage, postoperative drainage fluid, (BALF), nasopharynx swabs and sputum in alveolar lavage fluid were retrospectively analyzed. To analyze the distribution of SAU infection and the trend of drug resistance to antibiotics in common use. Results from January 2012 to December 2014, 98 127 samples were examined, 20,132 of them were positive, the positive rate was 20.52%, the positive rate of SAU was 1 053, the positive rate was 5.23%, the positive rate was 20.52%, the positive rate was 5.23%. 464 samples from qualified lower respiratory tract, 208 from secretion / abscess puncture / drainage, 60 from nasopharyngeal swabs, accounting for 44.07%, 19.75%, 5.70%, respectively. The distribution rate of SAU in respiratory department was 17.19%, 15.95% and 11.30% in paediatrics and ICU, respectively. The resistance rate of SAU to ceftriaxone, ampicillin / sulbactam and tetracycline was significantly different (P0.05), and the resistance rates to penicillin G, oxacillin, amoxicillin / clavulanate and cefazolin were significantly different. There was no significant difference between the two groups. No vancomycin-resistant or linazosin-resistant strains were found. The (MRSA) detection rates of methicillin-resistant Staphylococcus aureus were 43.30%, 38.10% and 37.10%, respectively. There was no significant difference between the two groups. Conclusion SAU plays an important role in all systemic infections of inpatients, and the resistance rate of SAU to different antimicrobial agents is different.
【作者单位】：成都市第三人民医院暨重庆医科大学附属成都第二临床学院检验科;成都市第三人民医院暨重庆医科大学附属成都第二临床学院儿科;
【基金】：国家自然基金资助项目(31500077) 四川省科技厅应用基础研究基金资助项目(2013JY0121)
【分类号】：R197.32;R446.5

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