1400名0～5岁健康儿童血清抗苗勒氏管激素及抑制素B临床检测研究

发布时间：2019-06-26 13:55

【摘要】：目的检测0~5岁健康儿童血清抗苗勒氏管激素(AMH)及抑制素B(INHB)浓度,为建立正常参考范围提供帮助。方法选择来自上海市儿童医院、深圳市儿童医院、天津医科大学总医院、江西省儿童医院及成都市妇女儿童中心医院的健康体检男童及女童各700名,共1400名。根据年龄分为7组:0~1个月;1~6个月;6个月至1岁;1~2岁;2~3岁;3~4岁;4~5岁,其中每组男童及女童各100名。采用酶联免疫吸附法(ELISA)检测血清AMH浓度(μg/L)及INHB浓度(ng/L)。结果 0~5岁健康男童血清AMH浓度在1~6个月达高峰210.70(55.37~439.45)μg/L,1~5岁维持平稳低水平147.10(17.69~321.88)ng/L;女童血清AMH浓度在1~6个月也出现小高峰1.77(0.06~7.68)ng/L,2~5岁趋于平稳为1.98(0.19~7.31)ng/L。男童血清INHB浓度在1~6个月达高峰274.23(0.00~602.34)ng/L,女童1~6个月出现小高峰为36.83(0.00~226.32)ng/L。结论提供了多中心及大样本0~5岁健康儿童血清AMH及INHB值的浓度范围,并发现1~6个月年龄段出现浓度高峰。
[Abstract]:Objective to detect the serum levels of anti-Muller's tube hormone (AMH) and inhibin B (INHB) in healthy children aged 0 to 5 years old, and to provide help for the establishment of normal reference range. Methods A total of 1400 boys and girls from Shanghai Children's Hospital, Shenzhen Children's Hospital, Tianjin Medical University General Hospital, Jiangxi Provincial Children's Hospital and Chengdu Women's and Children's Center Hospital were selected. According to the age, they were divided into 7 groups: 0 鈮，

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