辽宁省一般人群全血和尿液中铬水平分析

发布时间：2019-07-04 15:42

【摘要】：目的了解2009—2010年辽宁省一般人群全血和尿液中铬水平(以下简称血铬、尿铬),分析其流行病学特点。方法 2009—2010年采用整群随机抽样方法,从辽宁省内东、中、西部3个城市抽取2 105名6~60岁一般人群作为研究对象,对其生活环境和健康状况问卷调查,并分别采集2 105份静脉抗凝血和1 691份尿样,应用电感耦合等离子体质谱法检测血铬、尿铬水平,分析不同年龄、性别和区域人群的分布情况。结果辽宁省一般人群血铬几何均数为0.53μg/L,中位数为0.3μg/L,P95为2.92μg/L;男性和女性几何均数分别为0.49、0.58μg/L(P0.01);6~12、13~16、17~20、21~30、31~45、46~60岁年龄组血铬几何均数分别为0.38、0.57、0.66、0.55、0.57和0.52μg/L(P0.01);东、中、西部地区人群血铬几何均数分别为0.32、1.23、0.42μg/L(P0.01)。辽宁省一般人群尿铬几何均数低于检出限0.42μg/L,对不同特征中尿铬高于检出限人数分布比较结果显示,不同年龄、地域人群尿铬水平差异有统计学意义(P0.01)。结论辽宁省血铬、尿铬水平均低于全国一般人群血铬、尿铬水平,本研究为进一步开展铬的生物监测、鉴别排除职业禁忌症等研究提供了基础数据。
[Abstract]:Objective to investigate the levels of chromium in whole blood and urine (hereinafter referred to as blood chromium, urine chromium) in Liaoning province from 2009 to 2010, and to analyze its epidemiological characteristics. Methods from 2009 to 2010, 2105 general population aged 6 years old and 60 years old were selected from three cities of Inner East, Middle and West Liaoning Province as subjects. 2105 intravenous anticoagulant and 1691 urine samples were collected. Blood chromium and urine chromium levels were measured by inductively coupled plasma mass spectrometry (ICP-MS). The distribution of different age, sex and regional population was analyzed. Results the geometric mean of blood chromium was 0.53 渭 g / L, the median was 0.3 渭 g / L, P95 was 2.92 渭 g / L, the geometric mean of male and female was 0.49 渭 g / L, 0.58 渭 g / L (P 0.01), and the geometric mean of blood chromium was 0.38, 0.67, 0.56, 0.57 and 0.52 渭 g / L, respectively, in the age groups of 6: 12, 13: 16, 17: 20, 31 卤45, 46 渭 g / L, 0.38 渭 g / L, 0.67 渭 g / L, 0.55 渭 g / L, 0.57 渭 g / L, 0.52 渭 g / L, 0.38 渭 g / L, 0.67 渭 g / L, 0.56 渭 g / L, 0.57 渭 g / L and 0.52 渭 g / L, respectively. The geometric mean of blood chromium was 0.32, 1.23 渭 g / L and 0.42 渭 g / L in the east, middle and west respectively (P 0.01). The geometric mean of urinary chromium in Liaoning Province was lower than the detection limit of 0.42 渭 g / L. The results showed that there was significant difference in urinary chromium level among different ages and regions (P 0.01). Conclusion the average levels of blood chromium and urine chromium in Liaoning Province are lower than those in the general population in China. This study provides basic data for further biological monitoring of chromium and identification and exclusion of occupational contraindications.
【作者单位】：丹东市疾病预防控制中心;沈阳市劳动卫生职业病研究所;中国疾病预防控制中心职业卫生与中毒控制所化学污染与健康安全重点实验室;辽宁医学院;
【基金】：卫生部行业科研专项(200802020) 国家科技支撑计划(2006Bal106B02) 沈阳市科学计划项目(1091165-9-00)
【分类号】：R446.1

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