替加环素、米诺环素对VanM型万古霉素耐药屎肠球菌体外抗菌活性

发布时间：2019-08-09 12:23

【摘要】：目的了解替加环素及米诺环素对Van M型万古霉素耐药屎肠球菌临床分离株的体外抗菌活性。方法收集2006—2014年上海地区临床分离Van M型万古霉素耐药屎肠球菌45株;采用PCR扩增及测序确认菌种和万古霉素耐药基因型;测定替加环素及米诺环素等10种抗菌药物对Van M型万古霉素耐药屎肠球菌的MIC。结果 45株临床分离株均确认为Van M型万古霉素耐药屎肠球菌;所有菌株对万古霉素高度耐药(MIC 128~256 mg/L),对替考拉宁耐药率为71.1%。几乎所有菌株对左氧氟沙星(100%)和氨苄西林(97.8%)耐药,对米诺环素、庆大霉素和利福平的耐药率分别为15.6%、64.4%和82.2%,未检出替加环素和利奈唑胺耐药株。结论替加环素和米诺环素对Van M型万古霉素耐药屎肠球菌有良好的体外抗菌活性。
[Abstract]:Objective to investigate the in vitro antibacterial activity of tegacycline and minocycline against Van M vancomycin resistant Enterococcus faecalis clinical isolates. Methods 45 strains of Van M vancomycin resistant enterococcus were collected from Shanghai from 2006 to 2014. The strains and vancomycin resistant genotypes were confirmed by PCR amplification and sequencing, and the MIC. of 10 antibiotics, such as tegacycline and minocycline, to Van M vancomycin resistant enterococci were determined. Results 45 clinical isolates were identified as Van M vancomycin resistant enterococcus, and all strains were highly resistant to vancomycin (MIC 128 鈮，

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