连续流反应技术开发及其在制药危险工艺中的应用
发布时间：2018-07-22 14:02
【摘要】：当前,化学制药过程仍然存在许多极易导致泄漏、火灾、爆炸、中毒的工艺——"危险工艺"。传统间歇釜式生产方式存在传质传热效率低、产品质量稳定性差、生产效率低等缺点,尤其在处理"危险工艺"过程中,釜式反应过程安全隐患大。而连续流反应技术具有在线反应量少、传质传热效率高、参数控制精确、工艺稳定、安全高效等优点,能使"危险工艺"在安全高效的可控模式下运行。本文主要介绍连续流反应技术在光气及光气化、氯化、硝化等典型"危险工艺"中的成功应用案例,进一步阐明连续流反应技术的显著优点。
[Abstract]:At present, there are still many chemical pharmaceutical processes that can easily lead to leakage, fire, explosion and poisoning-"dangerous process". The traditional batch reactor production method has some disadvantages such as low heat transfer efficiency, poor product quality stability, low production efficiency and so on. Especially in the process of dealing with "dangerous process", the safety hidden danger of the reactor reaction process is great. The continuous flow reaction technology has the advantages of little reaction quantity, high heat transfer efficiency, precise parameter control, stable process and high safety and high efficiency. It can make the "dangerous process" run in a safe and efficient controllable mode. This paper mainly introduces the successful application of continuous flow reaction technology in typical "dangerous processes" such as phosgene and photogasification, chlorination and nitrification, and further illustrates the remarkable advantages of continuous flow reaction technology.
【作者单位】： 浙江工业大学长三角绿色制药协同创新中心;
【分类号】：TQ086;TQ460
本文编号：2137697
[Abstract]:At present, there are still many chemical pharmaceutical processes that can easily lead to leakage, fire, explosion and poisoning-"dangerous process". The traditional batch reactor production method has some disadvantages such as low heat transfer efficiency, poor product quality stability, low production efficiency and so on. Especially in the process of dealing with "dangerous process", the safety hidden danger of the reactor reaction process is great. The continuous flow reaction technology has the advantages of little reaction quantity, high heat transfer efficiency, precise parameter control, stable process and high safety and high efficiency. It can make the "dangerous process" run in a safe and efficient controllable mode. This paper mainly introduces the successful application of continuous flow reaction technology in typical "dangerous processes" such as phosgene and photogasification, chlorination and nitrification, and further illustrates the remarkable advantages of continuous flow reaction technology.
【作者单位】： 浙江工业大学长三角绿色制药协同创新中心;
【分类号】：TQ086;TQ460
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