基于离子液体溶剂的壳聚糖膜的制备与力学性能研究

发布时间：2018-01-04 13:09

本文关键词：基于离子液体溶剂的壳聚糖膜的制备与力学性能研究　出处：《青岛科技大学》2015年硕士论文　论文类型：学位论文

【摘要】：壳聚糖具有良好的成膜性、抑菌性,在医药领域应用广泛,因此对壳聚糖膜的制备研究受到了广大学者关注。鉴于离子液体的结构可设计性、难挥发、热稳定性好、溶解能力强等优点,本文将其水溶液作为溶解壳聚糖及丁基壳聚糖的优良溶剂,制备壳聚糖及丁基壳聚糖膜,并与常规体系的制膜工艺进行对比研究。研究发现,离子液体体系下制备的壳聚糖膜及丁基壳聚糖膜的力学性能、热稳定性均较常规体系有所改善,而且丁基壳聚糖膜更易被降解吸收,为壳聚糖及其衍生物在生物医用领域的应用奠定了理论基础。本文设计并合成了一系列氨基酸类及咪唑类离子液体,考察了壳聚糖及丁基壳聚糖在上述水溶液中的溶解度,筛选出1-羧甲基-N-甲基咪唑氯盐([Acmim]Cl)、甘氨酸盐酸盐([Gly]C1)分别用于溶解壳聚糖、丁基壳聚糖,并对再生的壳聚糖、丁基壳聚糖及原料进行分子量测定和表征。结果发现,在溶解过程中,壳聚糖与丁基壳聚糖发生不同程度的降解,但其主体结构保持不变,没有与离子液体发生反应。在HAc常规体系和[Acmim]Cl离子液体体系下制备壳聚糖膜,并进行单因素实验得到的最佳工艺条件。实验测得,HAc体系壳聚糖膜的断裂强度为176.58MPa,伸长率为4.06%,初始模量为2.09 GPa; [Acmim]Cl离子液体体系壳聚糖膜的断裂强度为190.02 MPa,伸长率为3.93%,初始模量为3.53 GPa。结果表明,离子液体体系壳聚糖膜力学性能优于HAc体系壳聚糖膜,膜表面较光滑,热稳定性较好,溶胀度较小,孔隙率较小,降解率较低。在HAc常规体系和[Gly]Cl离子液体体系下制备丁基壳聚糖膜,并进行单因素实验得到的最佳工艺条件。实验测得,HAc体系丁基壳聚糖膜的断裂强度为152.24 MPa,伸长率为3.17%,初始模量为2.93 GPa；离子液体体系丁基壳聚糖膜的断裂强度为168.871MPa,伸长率为3.72%,初始模量为2.41 GPa。结果表明,离子液体体系丁基壳聚糖膜力学性能优于HAc体系丁基壳聚糖膜,膜表面较光滑,热稳定性较好,溶胀度较小,孔隙率较小,降解率较低。同时,丁基壳聚糖膜的力学性能略低于壳聚糖膜,易热分解,但其溶胀度、孔隙率以及降解率均高于壳聚糖膜。
[Abstract]:Chitosan has good film-forming and bacteriostatic properties, and has been widely used in the field of medicine. Therefore, the preparation of chitosan membrane has attracted the attention of many scholars. In view of the structure design of ionic liquids, it is difficult to volatilize. In this paper, the aqueous solution of chitosan and Ding Ji chitosan was used as an excellent solvent to prepare chitosan and Ding Ji chitosan membrane. The results show that the mechanical properties and thermal stability of chitosan film and Ding Ji chitosan membrane prepared in ionic liquid system are better than those in conventional system. Ding Ji chitosan film is more easily degraded and absorbed, which lays a theoretical foundation for the application of chitosan and its derivatives in the field of biomedical. In this paper, a series of amino acids and imidazole ionic liquids were designed and synthesized. The solubility of chitosan and Ding Ji chitosan in the above aqueous solution was investigated, and 1-carboxymethyl -N-methyl imidazole chloride salt was screened out. [Acmim, glycine hydrochloride. [Gly] C _ 1) was used to dissolve chitosan and Ding Ji chitosan respectively, and the molecular weight of regenerated chitosan, Ding Ji chitosan and raw materials were determined and characterized. Chitosan and Ding Ji were degraded to varying degrees, but their main structure remained unchanged and did not react with ionic liquids. [Chitosan membrane was prepared in Acmim] Cl ionic liquid system, and the optimum technological conditions were obtained by single factor experiment. The fracture strength of chitosan membrane in HAC system was 176.58 MPA. The elongation is 4.06 and the initial modulus is 2.09 GPa. [The breaking strength, elongation and initial modulus of chitosan membrane of Acmim] Cl ionic liquid system were 190.02 MPA, 3.93 and 3.53 GPA, respectively. The mechanical properties of chitosan membrane in ionic liquid system are better than those in HAc system. The surface of the membrane is smooth, the thermal stability is better, the swelling degree is smaller, the porosity is smaller, the degradation rate is lower. [Ding Ji chitosan membrane was prepared in Gly] Cl ionic liquid system, and the optimum technological conditions were obtained by single factor experiment. The breaking strength, elongation and initial modulus of Ding Ji chitosan membrane in HAc system were 152.24 MPA, 3.17 and 2.93 GPA, respectively. The breaking strength, elongation and initial modulus of Ding Ji chitosan membrane were 168.871 MPa, 3.72 and 2.41 GPa. The mechanical properties of Ding Ji chitosan membrane in ionic liquid system were better than those in HAc system, such as smooth surface, good thermal stability, low swelling degree, low porosity and low degradation rate. The mechanical properties of Ding Ji chitosan film were slightly lower than those of chitosan film and could be decomposed easily, but the swelling degree, porosity and degradation rate of Ding Ji chitosan film were higher than that of chitosan film.
【学位授予单位】：青岛科技大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：O636.1;TB383.2

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