锂皂石基抗菌材料的制备及其性能的研究

发布时间：2018-01-11 22:30

  本文关键词：锂皂石基抗菌材料的制备及其性能的研究　出处：《天津工业大学》2017年硕士论文　论文类型：学位论文

  更多相关文章： 锂皂石 壳聚糖 抗菌性能 β-环糊精

【摘要】：近年来,随着社会的快速发展和人们生活水平的提高,人们对生活品质的要求也越来越高,但是细菌、霉菌等有害微生物却时时刻刻的威胁着我们的生活。因此亟待研究出一种高效的抗菌材料。本课题选用一种相比于其他硅酸盐具有较大的比表面积、较高的阳离子交换容量和显著的膨胀性能的新型层状硅酸盐-锂皂石为原料,分别采用溶液插层法和表面改性法对其进行改性,从而制备具有吸附菌和杀菌双重功效的锂皂石。首先采用溶液插层法对锂皂石进行改性,利用多种季铵盐改性锂皂石,通过XRD和抗菌性能强弱逐级筛选,得出最佳的制备工艺,即反应温度为80℃,最佳的反应时间为8 h,反应比例为1:2。然后以十四烷基三甲基溴化铵、十六烷基三甲基溴化铵、壳聚糖和锂皂石为原料制备壳聚糖/有机锂皂石复合物,运用FTIR、XRD、SEM、TEM等分析手段对其结构和形貌特征进行了表征。利用抑菌圈、平板计数法、TTC显色和内膜渗透性等对壳聚糖/有机锂皂石复合物的抗菌性能进行分析。其次,实验采用表面改性的方法使锂皂石表面接枝β-环糊精,首先利用硅烷偶联剂制备胺基化有机锂皂石,然后利用丁二酸酐制备羧基化有机锂皂石,最后制备出β-环糊精接枝有机锂皂石,并研究pH和初始浓度对β-环糊精接枝有机锂皂石的包封率的影响。利用多种表征手段对产物的结构、抗菌性能、药物释放动力学等方面进行研究。本研究成功利用两种改性方法完成了对锂皂石的改性,制备的壳聚糖/十四烷基三甲基溴化铵/锂皂石对大肠杆菌的抗菌率为100.0%,对金黄色葡萄球菌的抗菌率为85.3%,壳聚糖/十六烷基三甲基溴化铵/锂皂石对大肠杆菌的抗菌率为99.9%,对金黄色葡萄球菌的抗菌率为99.9%。制备的氨苄青霉素/β-环糊精接枝有机锂皂石对大肠杆菌的抗菌率为95.9%,对金黄色葡萄球菌的抗菌率为100.0%,其药物释放机制为Fick扩散。
[Abstract]:In recent years, with the rapid development of society and the improvement of people's living standard, people's request for quality of life is higher and higher, but bacteria. The harmful microorganism such as mold is threatening our life all the time. Therefore, it is urgent to develop a kind of high efficiency antibacterial material. In this study, one kind of silicate has a larger specific surface area than other silicate. The new layered silicate-lithium-soap with high cation exchange capacity and remarkable expansibility was modified by solution intercalation method and surface modification method respectively. In order to prepare lithium-soaponite with adsorption bacteria and bactericidal effect. Firstly, the lithium-soaponite was modified by solution intercalation method, and the lithium-saponite was modified by a variety of quaternary ammonium salts. The XRD and antibacterial properties were screened step by step. The optimum preparation process was obtained, that is, the reaction temperature was 80 鈩，

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