金纳米粒的体内过程研究进展

发布时间：2018-01-20 01:46

本文关键词： 金纳米粒体内研究吸收分布代谢排泄　出处：《中国药房》2016年19期 　论文类型：期刊论文

【摘要】：目的:为促进金纳米粒的进一步研究提供参考。方法:以"金纳米粒""体内""代谢""Gold nanoparticles""in vivo""Metabolize"等为关键词,组合检索1997-2015年在Pub Med、OSA、ACS、Springer Link、中国知网、万方、维普等数据库中的有关文献,对金纳米粒在体内吸收、分布、代谢、排泄等内容进行综述。结果与结论:共查询到相关英文文献300余篇、中文文献800余篇,其中有效文献29篇。金纳米粒的体内过程与其形状、粒径、表面电荷和表面修饰物有着紧密的关系,其在体内吸收与分布的量与粒径呈反比,影响其在体内代谢和排泄的两个重要因素是粒径和表面电荷。因此,可以根据不同情况,改变金纳米粒子的粒径、表面电荷、表面修饰物等,以达到提高靶向性、降低毒副作用的目的。
[Abstract]:Objective: to provide reference for promoting the further research of gold nanoparticles. Methods: to "NPs" "body" and "metabolism" and "Gold nanoparticles" and "in vivo" and "Metabolize" as key words in 1997-2015 Pub searching Med, OSA, ACS, Springer, Link, Wanfang, China HowNet, relevant literature VIP database, the NPs in the in vivo absorption, distribution, metabolism, excretion and other content were reviewed. Results and conclusion: a total of English query to the relevant documents more than 300 articles, Chinese documents more than 800 articles, of which 29 effective literatures. In the process of gold nanoparticles and its shape, particle size, surface charge and surface modification of a close relationship, the in vivo absorption and distribution of amount and particle size is inversely proportional to its influence is the particle size and surface charge in two important factors in vivo metabolism and excretion. Therefore, according to the different situation, changing the gold nanoparticle size, surface charge Charge, surface modifier, etc., in order to improve the targeting and reduce the side effects of toxic and side effects.

【作者单位】：黑龙江中医药大学药学院;
【基金】：黑龙江省教育厅科学技术研究项目(No.12521z022)
【分类号】：R944;TB383.1
【正文快照】： 金纳米粒(Gold nanoparticles,GNPs)由于其低毒、粒径可控、较好的生物相容性、具备表面等离子体共振光学现象等特点在科学界受到广泛的关注[1]。其本身具有一定的光学热效应和生物活性,表面易被修饰[2],修饰后可以通过共价或非共价结合、静电吸附、包封等方式与各种药物结合[

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