埃洛石纳米管在生物医学应用中的研究进展

发布时间：2018-02-25 15:19

本文关键词： 埃洛石纳米管载体酶固定化药物/基因靶向传递生物成像　出处：《化工进展》2017年08期 　论文类型：期刊论文

【摘要】：埃洛石纳米管(HNTs)是一种新型的天然硅铝酸盐类纳米材料,具有独特的纳米管状结构及比表面积大、反应活性高等优点,近年来在生物医学运输领域中突显出愈来愈重要的应用价值。本文简述了HNTs的结构和性质,分析了HNTs在生物医学领域应用的可行性,重点阐述了其在酶固定化、生物显像、生物支架、药物及基因靶向运输治疗等生物医学方面的研究和应用现状,并指出了在上述应用领域中HNTs相对于传统无机纳米材料具有固载效果好、易于化学修饰、生物相容性高、毒性低、靶向选择性高等诸多优势。最后指出了目前HNTs在生物医学领域应用中还存在医疗成果转换周期长、成本效益高和药物释放作用机理不明确等挑战,并对其在疾病诊断、靶向递送药物及追踪治疗效果等一系列现代医疗技术的前景进行了展望。
[Abstract]:HNTs is a new type of natural aluminosilicate nanomaterials with unique nanotube structure, large specific surface area, high reaction activity and so on. In recent years, the application value of HNTs has become more and more important in the field of biomedical transportation. In this paper, the structure and properties of HNTs are briefly described, the feasibility of its application in biomedical field is analyzed, and the application of HNTs in enzyme immobilization and bioimaging is emphasized. The research and application status of biomedical fields such as biomedical stents, drugs and gene targeted transport therapy, etc. It is pointed out that HNTs has better immobilization effect than traditional inorganic nanomaterials, and is easy to be modified chemically. Many advantages such as high biocompatibility, low toxicity, high targeting selectivity and so on are pointed out. Finally, it is pointed out that the application of HNTs in biomedical field still has many challenges, such as long conversion period of medical achievements, high cost effectiveness and unclear mechanism of drug release. The prospects of a series of modern medical technologies such as disease diagnosis, targeted delivery of drugs and tracking of therapeutic effects are also prospected.
【作者单位】：天津大学化工学院天津市应用催化科学与工程重点实验室;
【分类号】：R318;TB383.1

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