壳聚糖模板法制备硅基多孔材料及药物缓释性能研究

发布时间：2018-02-26 19:28

本文关键词： 硅基多孔材料壳聚糖模板法药物运输左氧氟沙星　出处：《延边大学》2015年硕士论文　论文类型：学位论文

【摘要】：多孔硅基材料是一种由相互贯通或封闭的孔洞构成网络结构的材料,因其孔径的可控分布,大的比表面积,优良的吸附与催化性能,在生化、环境、电化学和药物运载与控释技术方面有巨大的应用潜力。多孔材料是以表面活性剂或合成高分子形成的超分子结构为模板,利用溶胶一凝胶工艺,通过有机物和无机物之间的界面定向导引作用组装成一类孔径在约1.5-30 nm之间、孔径分布窄且有规则孔道结构的无机多孔材料。天然生物高分子因其无毒、可降解和自然界的储量丰富且不可替代等优点,在多孔材料的合成研究中受到很大的重视。其中,壳聚糖是自然界存在的唯一带正电荷的天然生物高分子,可在水溶液中起类似阳离子表面活性剂的作用,有可能代替有机阳离子表面活性剂而在多孔材料合成研究领域备受关注。本文选用以壳聚糖为模板,用正硅酸乙酯(TEOS)为硅源和九水硝酸铝为酸性活性剂,成功合成了硅基复合多孔材料。通过扫描电子显微镜(TEM)、透射电子显微镜(SEM)、N2吸附脱附(BET)和热重量分析(TG)等手段进行表征,以及在体外药物释放行为的研究。结果显示合成的壳聚糖模板化的掺杂铝离子的Si02纳米复合材料有高度特殊的表面积(244-607m2/g),总孔容(0.19-0.34 cm3/g)和窄的孔径分布。Si02纳米复合多孔材料作为左氧氟沙星的药物载体来研究药物释放行为,有良好的缓释效果。最后对Si02纳米复合多孔材料和未加氧化铝的壳聚糖(CS)/SiO2复合多孔材料对MB染料进行吸附,结果表明掺杂铝离子的Si02纳米复合多孔材料对染料有较高的吸附率。
[Abstract]:Porous silicon based materials are composed of interpenetrating or closed pores, because of their controllable pore size distribution, large specific surface area, excellent adsorption and catalytic performance, in biochemistry, environment, Electrochemistry and drug delivery and controlled release techniques have great potential applications. Porous materials are based on surmolecular structures formed by surfactants or synthetic polymers, using sol-gel processes. A class of inorganic porous materials with pore size between 1.5-30 nm and narrow pore size distribution with regular pore structure were assembled through the interface directional guidance between organic and inorganic compounds. Biodegradable and natural reserves are abundant and irreplaceable. Chitosan is the only positively charged natural biopolymers in nature due to its great importance in the synthesis of porous materials. It can act as a cationic surfactant in aqueous solution, and may replace organic cationic surfactant in the field of porous materials synthesis. In this paper, chitosan is used as template. Si-based composite porous materials were successfully synthesized by using tetraethyl orthosilicate (TEOS) as silicon source and aluminum nitrate pentahydrate as acidic active agent. Si-based composite porous materials were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), absorption and desorption of N 2 (BET) and thermogravimetric analysis (TG). And in vitro drug release behavior. The results show that the synthesized chitosan template doped Si02 nanocomposites have a high surface area of 244-607 m2 / g, total pore volume 0.19-0.34 cm 3 / g) and narrow pore size distribution .Si02 nanocomposite. Porous materials are used as drug carriers of levofloxacin to study drug release behavior. Finally, Si02 nano-composite porous materials and chitosan / Sio _ 2 composite porous materials without alumina were adsorbed on MB dyes. The results showed that Si02 nano-composite porous materials doped with aluminum ions had a high adsorption rate for dyes.
【学位授予单位】：延边大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：TB383.4;TQ460.1

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