羟基磷灰石复合材料的制备与性能研究

发布时间：2018-03-27 08:08

  本文选题：羟基磷灰石　切入点：壳聚糖　出处：《东华大学》2016年硕士论文

【摘要】：羟基磷灰石(HAP)复合材料是利用材料复合技术,在HAP中加入第二相或者多相组分制备而得,既具备HAP的生物相容性和生物活性,同时有机大分子优良的加工性能和韧性也得到了利用。本研究分别采用具有生物相容性的壳聚糖(CS)、羧甲基纤维素钠(CMC)和β-环糊精(β-CD)作为基质,加入合成HAP所需要的钙源和磷源,利用大分子的结构差异,诱导HAP在基质上的生长,原位合成有机分子/羟基磷灰石复合材料。通过对复合材料的性能进行表征,分析不同条件下合成的HAP复合材料的结构组成和形貌,并探讨HAP与不同有机大分子之间的复合机理。首先利用原位合成法制备CS/HAP复合膜,借助傅里叶变换红外光谱(FT-IR)、热重分析(TG)、扫描电镜(SEM)对CS/HAP复合膜进行表征,并对复合膜的吸水性、尺寸稳定性、力学性能、润湿性进行了测试分析。结果表明CS的-NH2和HAP的-OH参与了CS和HAP之间的复合;无机HAP在CS有机基质中均匀分布,CS/HAP复合膜具有层状结构;CS/HAP复合膜的吸水率低于CS膜,使得复合膜在湿态条件下的尺寸稳定性提高;CS/HAP复合膜的拉伸强度高于CS膜,这是由于CS/HAP复合膜含有层状结构,当受到外力作用时,通过CS中-NH2与HAP中-OH的相互作用,可以实现力的传递;同时CS/HAP复合膜的热稳定性也得到了一定的提高。采用与制备CS/HAP复合膜类似的方法合成CMC/HAP复合膜,利用FT-IR、TG和SEM对CMC/HAP复合膜进行表征,对复合膜的吸水性、尺寸稳定性、力学性能、润湿性进行了测试分析。结果表明CMC的-COO-和HAP的-OH参与了CMC和HAP的复合;加入HAP后可以改善CMC/HAP复合膜的吸湿性和尺寸稳定性;CMC/HAP复合膜的拉伸强度低于CMC膜;同时CMC/HAP复合膜的热稳定性得到了一定的提高。利用原位合成法分别在20℃和90℃条件下合成β-CD/HAP复合物,借助FT-IR、TG和SEM对反应产物进行了表征,研究温度和β-CD浓度对产物的组成、热稳定性、形貌等的影响。结果表明在碱性条件下,β-CD中C6位置上的-OH首先结合Ca2+,形成HAP的成核位点,然后HAP沿着β-CD自组装的分子长链生长,随着β-CD浓度的增大,制备的产物由最初的无规团聚逐渐变成针状、棒状结构。温度对复合物的形成也有一定的影响,低温条件下制备的复合物中含有较多的碳酸盐和磷酸盐副产物,提高反应温度可以减少副产物的生成,改善HAP在β-CD中分布的均匀性。
[Abstract]:Hydroxyapatite / apatite (HAP) composite was prepared by adding the second phase or multiphase component into HAP by using the composite technology of materials. It has the biocompatibility and bioactivity of HAP. At the same time, the excellent processability and toughness of organic macromolecules were also utilized. In this study, chitosan (CSC), carboxymethyl cellulose (CMCs) and 尾 -cyclodextrin (尾 -CD) were used as the substrates for the synthesis of HAP. The structure difference of macromolecules was used to induce the growth of HAP on the matrix. The organic molecule / hydroxyapatite composites were synthesized in situ. The properties of the composites were characterized. The structure and morphology of HAP composites synthesized under different conditions were analyzed, and the composite mechanism between HAP and different organic macromolecules was discussed. Firstly, CS/HAP composite films were prepared by in situ synthesis. The CS/HAP composite films were characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TG) and scanning electron microscopy (SEM). The wettability of CS / HAP composite membrane was tested and analyzed. The results showed that CS / HAP composite film had a lamellar structure and the water absorption of CS / HAP composite membrane was lower than that of CS / HAP composite membrane, and the inorganic HAP was uniformly distributed in CS / HAP composite membrane. The results showed that the water absorption rate of CS / HAP composite membrane was lower than that of CS / HAP composite membrane. The tensile strength of CS- / HAP composite film is higher than that of CS / HAP composite film under wet condition, which is due to the lamellar structure of CS/HAP composite membrane. When the composite membrane is subjected to external force, the interaction between -NH _ 2 in CS and -OH in HAP can be obtained by the interaction of -NH _ 2 in CS and -OH in HAP. At the same time, the thermal stability of the CS/HAP composite membrane was also improved. The CMC/HAP composite membrane was synthesized by using the method similar to the preparation of the CS/HAP composite membrane. The CMC/HAP composite membrane was characterized by FT-IRTG and SEM, and the water absorbency of the composite membrane was characterized by FT-IRTG and SEM. Dimensional stability, mechanical properties and wettability were tested and analyzed. The results showed that CMC and HAP -OH were involved in the combination of CMC and HAP. Adding HAP can improve the moisture absorption and dimensional stability of CMC/HAP composite membrane. The tensile strength of CMC / HAP composite membrane is lower than that of CMC film. At the same time, the thermal stability of CMC/HAP composite membrane was improved. 尾 -CD / HAP complex was synthesized by in-situ synthesis at 20 鈩，

本文编号：1670701