石英纳米通道单磷脂囊泡的电阻-脉冲分析方法（英文）

发布时间：2018-03-30 05:28

本文选题：电阻-脉冲分析方法　切入点：石英纳米通道　出处：《电化学》2017年02期

【摘要】：本文报告了用于检测单囊泡及其粒径分析的石英纳米通道电阻-脉冲分析方法.采用圆柱形石英纳米通道可检测粒径为100~300 nm的单磷脂囊泡和直径为170~400 nm的聚苯乙烯纳米颗粒.单囊泡和纳米颗粒的迁移可通过检测各自产生的方波电流脉冲信号,并由此确定颗粒尺寸.结果表明,采用石英纳米通道电阻-脉冲分析方法得到的颗粒/囊泡粒径与采用动态光散射法和扫描电子显微法得到的结果完全一致.这种基于电子的分析方法具有快速简单的特点,所用的自制微传感器廉价耐用.石英通道的应用还可与其它分析方法如电流分析法和荧光显微法联用,以获得生物囊泡及人工囊泡更完全的信息.
[Abstract]:A quartz nanochannel resistance - pulse analysis method for the detection of single vesicles and their particle size has been reported . Single - phospholipid vesicles with particle size of 100 - 300 nm and polystyrene nanoparticles with diameters of 170 - 400 nm can be detected by cylindrical quartz nano - channels . The particle size is determined by detecting the square - wave current pulse signals generated respectively . The results show that the particle size and particle size obtained by using the method of dynamic light scattering and scanning electron microscopy are quite consistent . The application of the quartz channel can also be combined with other analytical methods such as current analysis and fluorescence microscopy to obtain more complete information about the biological vesicles and artificial vesicles .

【作者单位】：美国华盛顿大学化学系;
【基金】：financial supports from the National Institutes of Health(GM101133) the University of Washington
【分类号】：O657.1;TB383.1

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