磁性纳米粒子的氨氧基修饰和多官能团链接分子的合成

发布时间：2018-04-04 02:28

本文选题：Fe3O4磁性纳米粒子　切入点：共沉淀法　出处：《湖南师范大学》2015年硕士论文

【摘要】：Fe3O4磁性纳米粒子由于其特殊性质被广泛使用,尤其是生命科学领域。表面未修饰的Fe3O4磁性纳米粒子易团聚和被氧化,分散性较差,磁性也会流失。在纳米粒子表面进行包裹或修饰可防止粒子被氧化,增加粒子的分散性及生物相容性,并进行表面功能化。表面功能化的Fe3O4磁性纳米粒子的功能化的特性和优良的磁性能,拓宽了Fe3O4磁性纳米粒子的应用范围。本论文通过采用操作简单,原料价廉的化学共沉淀法制备Fe3O4磁性纳米粒子,并用油酸对其进行包裹,讨论了两种粒子在转速分别为900 rpm、1000 rpm、1100 rpm、1200 rpm、1300 rpm、1400 rpm条件下对其粒径大小的影响,然后对Fe3O4磁性纳米粒子表面进行了有机功能化修饰,主要官能团有氨基、巯基和氧氨基等,并对其进行了SEM、TEM、XRD、TG、FT-IR等表征分析。经表征分析得出:未经油酸分子包裹的Fe3O4磁性纳米粒子分散性相差无几,粒径大约为10纳米左右,红外光谱也显示Fe3O4磁性纳米粒子表面成功连接上有机官能团如氨基和氧氨基。以在磁性纳米粒子上嫁接上多个官能团为目标,本论文还要以季戊四醇为骨架合成含多个官能团的支架。通过不同的选择性保护和脱保护策略,利用异丙叉基保护季戊四醇的两个羟基进行保护,再将剩余的羟基利用对甲苯磺酰氯进行活化,最后与硫代醋酸钾反应得到异丙叉基保护的单或双硫代乙酰基季戊四醇醚。为改善季戊四醇的空间位阻情况,将其中的两个碳链利用三缩四乙二醇进行了延长。本论文通过不同的保护和脱保护反应策略,共合成出三种不同的,分别具有氧氨基,巯基和羟基的季戊四醇类及三缩四乙二醇类有机链接小分子。
[Abstract]:Fe3O4 magnetic nanoparticles are widely used because of their special properties, especially in the field of life science.The unmodified Fe3O4 magnetic nanoparticles are easy to be agglomerated and oxidized.Encapsulation or modification on the surface of nanoparticles can prevent the particles from being oxidized, increase the dispersion and biocompatibility of the particles, and functionalize the surface.The functionalized properties and excellent magnetic properties of surface functionalized Fe3O4 magnetic nanoparticles broaden the application range of Fe3O4 magnetic nanoparticles.In this paper, Fe3O4 magnetic nanoparticles were prepared by chemical coprecipitation method with simple operation and cheap raw materials, and encapsulated with oleic acid. The effects of two kinds of particles on the particle size at the rotating speed of 900rpmC100rpmC1100rpmC1100rpmC1200rpmC1300rpmC1400 rpm were discussed.Then the surface of Fe3O4 magnetic nanoparticles was modified by organic functionalization. The main functional groups were amino, sulfhydryl and oxylamino, etc.The characterization and analysis showed that the dispersion of Fe3O4 magnetic nanoparticles without oleic acid molecule was about 10 nanometers. The infrared spectra also showed that the surface of Fe3O4 magnetic nanoparticles was successfully bonded with organic functional groups such as amino and oxo amino groups.In order to graft several functional groups onto magnetic nanoparticles, pentaerythritol was used as skeleton to synthesize scaffolds with multiple functional groups.The two hydroxyl groups of pentaerythritol were protected by isopropanyl group and the remaining hydroxyl groups were activated by p-toluenesulfonyl chloride through different selective protection and deprotection strategies.Finally, mono- or dithioacetylpentaerythritol ethers were obtained by reaction with potassium thioacetate.In order to improve the steric resistance of pentaerythritol, two of the carbon chains were extended by triethylene glycol.In this paper, three kinds of organically linked molecules of pentaerythritol and tetraethylene glycol were synthesized by different protection and deprotection strategies.
【学位授予单位】：湖南师范大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：TB383.1;O614.811

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