四氧化三铁纳米粒子表面接枝聚L-谷氨酸苄酯多孔微载体的构建和性能

发布时间：2018-04-09 23:17

本文选题：四氧化三铁　切入点：聚L-谷氨酸苄酯　出处：《高等学校化学学报》2017年07期

【摘要】：在氨基化改性的四氧化三铁(Fe_3O_4)纳米粒子表面引发N-羧酸酐L-谷氨酸苄酯(BLG-NCA)开环聚合,制得四氧化三铁/聚L-谷氨酸苄酯(PBLG)复合材料(Fe_3O_4-g-PBLG).改变单体和引发剂比例可以调控Fe_3O_4-g-PBLG的接枝率,采用热失重分析(TGA)测得实际接枝率分别为66.36%,79.66%和89.52%.通过双乳液挥发法制备磁性Fe_3O_4-g-PBLG多孔微载体,其中接枝率为89.52%的微载体密度为1.034 g/m L,孔隙率为92.57%,粒径为200~300μm,孔径为40~50μm,保水率为370%~400%.同时Fe_3O_4-g-PBLG微载体具有超顺磁性,在外加磁场作用下可排布成任意形状,对治疗复杂结构的骨缺损具有显著优势.因此Fe_3O_4-g-PBLG多孔微载体在骨组织工程领域具有潜在应用价值.
[Abstract]:Fe _ 3O _ 4-g-PBLGG / Fe _ 3O _ 4-g-PBLGN / Fe _ 3O _ 4-g-PBLGG / Fe _ 3O _ 4-g-PBLGG / Fe _ 3O _ 4-g-PBLGg composite were prepared by ring-opening polymerization of N-carboxylic anhydride L-glutamate benzyl ester (BLG-NCA) on the surface of the modified Fe _ 3O _ 4 / Fe _ 3O _ 4) nanoparticles.The grafting rate of Fe_3O_4-g-PBLG can be controlled by changing the ratio of monomer to initiator. The actual grafting rate measured by thermogravimetric analysis is 66.36% 79.66% and 89.52%, respectively.Magnetic Fe_3O_4-g-PBLG porous microcarriers were prepared by double emulsion evaporation method. The density of microcarriers grafted with 89.52% was 1.034 g / mL, the porosity was 92.57 渭 m, the diameter was 200 渭 m, the pore diameter was 4050 渭 m, and the water retention rate was 370 ~ 400 渭 m.At the same time, Fe_3O_4-g-PBLG microcarriers are superparamagnetic and can be arranged into any shape under the action of external magnetic field, which has a significant advantage in the treatment of complex bone defects.Therefore, Fe_3O_4-g-PBLG porous microcarriers have potential application value in bone tissue engineering.
【作者单位】：上海大学材料科学与工程学院高分子材料系;
【基金】：上海市科委基础研究重点项目(批准号:15JC1490400) 国家自然科学基金(批准号:51373094)资助~~
【分类号】：R318.08;TB383.4

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