微纳米功能性聚合物微球制备及应用研究

发布时间：2018-04-17 15:38

本文选题：胶体晶体 + pH-响应　；参考：《青岛大学》2017年硕士论文

【摘要】：聚合物微球较其他材料相比,因具有独特的物理、化学性能,近年来被广泛应用于光子晶体、药物靶向输送载体、催化剂、环境保护材料以及仿生材料等领域。胶体晶体是近年来比较热门的一种新兴材料,是制备光子晶体、特异性传感器等的重要方法。胶体晶体最直观的特点就是其具有绚丽的结构颜色,如何将其成功的应用于制备直观的传感器,是目前学术界的研究重点。微米级单分散多孔聚合物微球主要被应用于液相色谱柱填料,制备不同材料、性能的色谱柱填料,是未来科技发展的重中之重。本论文通过对无皂乳液聚合制备聚苯乙烯乳胶颗粒的方法进行改进,制备出具有pH响应性能的单分散纳米聚合物微球,并利用气液界面组装法制备出二维胶体晶体,并与原来制备的聚苯乙烯乳胶颗粒组装形成的胶体晶体对比,发现该胶体晶体具有较好的pH响应性能,并成功的将其应用于酸性溶液的检测。运用改进的两步种子聚合法以微米级单分散聚甲基丙烯酸甲酯微球(PMMA)作为种子成功的制备出尺寸约2.5μm的单分散聚甲基丙烯酸甲酯交联多孔微球,通过调整不同的致孔剂体系,能够得出具有多种不同表面形貌的单分散多孔微球,且以甲苯:DBP=1:1致孔剂体系下得到的微球的孔隙最小,比表面积最大,是用作液相色谱柱填料的理想材料。并将其用作色谱柱填料,能够成功的完成对精氨酸、甘氨酸和谷氨酸的分离,且分离效果佳,是运用液相色谱分离氨基酸的新材料。除此之外,还通过乳液聚合和无皂乳液聚合制备出单分散乳胶粒,在酸/碱处理后得到表面含有丰富羧基的多孔乳胶粒。在接下来的研究中,充分利用多孔乳胶粒表面羧基,拟制备出各种功能化胶体晶体传感器。本论文所研究的pH响应型胶体晶体具备了可通过肉眼直观的观察溶液pH的差异,对酸碱条件下形成的胶体晶体的结构发生明显变化,可应用于胶体晶体酸碱传感器。所研究的单分散多孔PMMA交联微球在作为色谱柱填料在分离蛋白质和氨基酸等方面具有一定的应用前景。以酸碱处理法制备多孔乳胶粒,功能化改性后组装智能响应胶体晶体传感器,具有较大的应用前景。
[Abstract]:Compared with other materials, polymer microspheres have been widely used in the fields of photonic crystals, drug targeting carriers, catalysts, environmental protection materials and bionic materials due to their unique physical and chemical properties.Colloidal crystal is a popular new material in recent years. It is an important method to prepare photonic crystals and specific sensors.The most intuitive feature of colloidal crystals is that they have brilliant structural colors. How to successfully apply them to the fabrication of intuitive sensors is the focus of academic research at present.Micron size monodisperse porous polymer microspheres are mainly used in liquid chromatographic column fillers to prepare chromatographic column fillers with different materials and properties, which are the most important in the development of science and technology in the future.In this paper, the method of preparing polystyrene latex particles by soap-free emulsion polymerization was improved to prepare monodisperse nano-polymer microspheres with pH response, and two-dimensional colloidal crystals were prepared by gas-liquid interface assembly method.Compared with the colloidal crystal assembled from the original polystyrene latex particles, it was found that the colloidal crystal had better pH response and was successfully applied to the detection of acidic solution.The modified two-step seed polymerization method was used to prepare the monodisperse polymethyl methacrylate crosslinked porous microspheres with the size of 2.5 渭 m by using micron size monodisperse polymethyl methacrylate microspheres (PMMA) as seeds. Different pore-forming agent systems were adjusted.The single dispersed porous microspheres with different surface morphologies can be obtained, and the microspheres with toluene: DBP 1: 1 pore-forming agent system have the smallest porosity and the largest specific surface area. It is an ideal material for liquid chromatographic column packing.The separation of arginine, glycine and glutamate can be successfully completed by using it as a column filler, and it is a new material for separation of amino acids by liquid chromatography.In addition, monodisperse latex particles were prepared by emulsion polymerization and soap-free emulsion polymerization. After acid / alkali treatment, porous latex particles with rich carboxyl groups were obtained.In the following studies, various functional colloidal crystal sensors were prepared by making full use of the carboxyl groups on the surface of porous latex particles.The pH-responsive colloidal crystals studied in this paper have obvious changes in structure of colloidal crystals formed under acid-base conditions, and can be used as acid-base sensors in colloidal crystals.The monodisperse porous PMMA crosslinked microspheres have a certain application prospect in separation of protein and amino acids as chromatographic column fillers.The porous latex particles were prepared by acid-base treatment and the intelligent response colloidal crystal sensor was assembled after functionalized modification.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TQ317;TB383.1

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