通过非常低强度的激光照射实现对皮肤安全的癌症光热治疗

发布时间：2018-04-17 16:58

本文选题：癌症 + 耐药性　；参考：《中国科学技术大学》2017年硕士论文

【摘要】：如何消灭肿瘤而不损伤皮肤是现在光热治疗所面临的一个挑战。本文中我们设计了对皮肤安全的癌症光热疗法,通过非常低剂量的光照射到聚多巴胺(PDA)纳米颗粒上,响应释放酸激活的溶血性聚合物(aHLP).在对皮肤安全的激光的照射下(功率密度为0.4W/cm2的850nm激光),我们设计的aHLP-PDA纳米颗粒能够产生足够的局部热量实现温和的光热治疗,同时通过热响应释放aHLP聚合物,利用肿瘤细胞外微环境呈酸性的特点,激活aHLP对癌细胞的选择性的细胞毒性。利用以上设计,我们在动物模型上证实,aHLP-PDA纳米颗粒能够在这样低的剂量照射下有效的抑制肿瘤的生长而不损害皮肤,从而有效的减轻原本肿瘤光热治疗中不可避免的皮肤损伤。这个纳米系统为对皮肤安全的光热疗法提供了有效途径。
[Abstract]:How to eliminate tumors without damaging the skin is a challenge for photothermal therapy.In this paper, we designed a skin safe photothermal therapy for cancer, which was irradiated to polydopamine (PDA) nanoparticles by very low dose of light, in response to the release of acid activated hemolytic polymer (HL-P).Under the irradiation of a safe laser on the skin (850nm laser with a power density of 0.4W/cm2), our designed aHLP-PDA nanoparticles can generate enough local heat for mild photothermal therapy, while releasing aHLP polymers through thermal response.In order to activate the selective cytotoxicity of aHLP to cancer cells, the microenvironment of tumor cells was acidic.Using the above design, we have demonstrated in animal models that HL-PDA nanoparticles can effectively inhibit tumor growth without damaging the skin at such a low dose of irradiation, thus effectively reducing the inevitable skin damage during photothermal therapy of the tumor.This nanosystem provides an effective approach to skin-safe photothermal therapy.
【学位授予单位】：中国科学技术大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R730.5;TB383.1

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