微通道并行模块化设计制造及规模化制备功能颗粒材料

发布时间：2018-04-27 18:24

本文选题：液滴微流控 + 微通道并行　；参考：《华东理工大学》2017年硕士论文

【摘要】：微流控技术在制备功能材料方面极具效率性和优势性,但是目前一直局限在实验室规模,制约着其产业化应用。本文基于微通道并行概念,围绕微通道并行放大规律以及微通道制造加工两条主线展开研究,旨在实现规模化制备功能材料的目标。本文创新性提出了多级模块化的微通道放大策略,并基于流阻模型建立了三维复杂分支管网的压力平衡模型,推导出模块的设计准则,揭示了放大参数、分配均匀性和通道设计参数之间的内在联系。在放大规律理论的指导下,基于激光雕刻技术以PMMA材料作为基板加工了八个通道阵列、十个阵列堆叠、五个堆叠模块集成的微流控放大系统,实现液滴微流控技术三级放大及规模化制备均匀液滴的目标。同时,研究了通道阵列放大和阵列堆叠放大所产生的放大效应。以壳聚糖体系为例,规模化制备了微米级的壳聚糖微球,在提升产量的同时保持了良好的单分散性。同时探索新型3D打印技术在成型微通道方面的应用。成型了三维结构微通道,验证了液滴制备与表面湿润特性无关性。采用数值模拟的方法研究了在重力作用下流体的分配性能,并以此作为指导,设计并3D打印了八通道竖直并行的微流控模块,实现了多通道并行规模化制备液滴的目标。以海藻酸钠体系为例,规模化制备了海藻酸钙微球。
[Abstract]:Microfluidic technology has high efficiency and superiority in the preparation of functional materials, but at present, it is limited in the scale of laboratory, which restricts its industrial application. Based on the concept of microchannel parallelism, this paper focuses on the microchannel parallel amplification law and microchannel manufacturing and processing, in order to achieve the goal of large-scale preparation of functional materials. In this paper, a multi-level modularized microchannel amplification strategy is proposed. Based on the flow resistance model, the pressure balance model of a three-dimensional complex branch pipe network is established, the design criteria of the module are derived, and the amplification parameters are revealed. The relationship between distribution uniformity and channel design parameters. Under the guidance of the amplification law theory, based on the laser engraving technology, the microfluidic amplification system with eight channel arrays, ten arrays stacked and five stacking modules is fabricated with PMMA material as the substrate. To achieve the goal of three-stage amplification and large-scale preparation of uniform droplets by droplet microfluidic technology. At the same time, the amplification effects of channel array amplification and array stacking amplification are studied. Taking chitosan system as an example, micrometer chitosan microspheres were prepared on a large scale, which kept good monodispersity while increasing yield. At the same time, the application of new 3D printing technology in shaping microchannel is explored. Three-dimensional microchannels were formed to verify that the preparation of droplets was independent of surface wetting characteristics. The distribution performance of fluid under gravity is studied by numerical simulation. Based on this, an eight-channel vertical parallel microfluidic control module is designed and 3D printed, which realizes the goal of multi-channel parallel large-scale preparation of droplets. Calcium alginate microspheres were prepared on a large scale with sodium alginate as an example.
【学位授予单位】：华东理工大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TB34

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