共轭有机荧光点分子的设计、合成及其细胞成像应用

发布时间：2018-05-26 06:01

本文选题：荧光成像 + 近红外荧光　；参考：《南京邮电大学》2017年硕士论文

【摘要】：荧光成像技术作为一种无创伤的技术,已被广泛用于跟踪和了解生物体内或体外复杂的环境,这在现代生命科学研究中都具有重要意义。与其他成像方式相比,荧光成像具有很高的时空分辨率。荧光成像的核心是荧光材料。因此,各种各样具有高荧光强度,良好光稳定性,高灵敏度,高信噪比,毒性低等特点的荧光材料已被设计和合成。本论文主要研究三种不同的共轭有机荧光材料在生物方面的应用,包括近红外荧光材料、固态荧光材料和热激活延迟荧光材料。具体主要包括下面三方面:(1)通过几种比较常见的合成方法制备了一种具有给体-受体-给体结构的材料TAT-DPP-TAT。一方面,由于常见的近红外的有机半导体荧光材料具有良好的光热效应,所以将材料TAT-DPP-TAT用于光热治疗;另一方面,由于中心体吡咯并吡咯二酮在光动力治疗方面具有良好的作用,所以进行了光动力治疗方面的测试,最终实现了材料的多应用。(2)本章通过对传统氟硼二吡咯材料结构的改变,设计合成了一种在固态状态下依然保持强荧光特性的材料。通过一系列的表征,研究其结构与性能的关系。(3)通过Cadogan关环设计合成了几种咔唑衍生物,然后通过一步法反应合成了几种具有给体-受体结构的热激活延迟荧光材料。通过对其性能的研究,主要包括其性能与结构之间的关系,并在有机电致发光器件中得到应用。
[Abstract]:As a non-invasive technique, fluorescence imaging technology has been widely used to track and understand the complex environment in vivo or in vitro, which is of great significance in modern life science research. Compared with other imaging methods, fluorescence imaging has high spatial and temporal resolution. The core of fluorescence imaging is fluorescent material. Therefore, various fluorescent materials with high fluorescence intensity, good light stability, high sensitivity, high signal-to-noise ratio and low toxicity have been designed and synthesized. In this paper, three kinds of conjugated organic fluorescent materials are studied in biological applications, including near infrared fluorescent materials, solid state fluorescent materials and thermal activated delayed fluorescence materials. A novel material with donor-receptor-donor structure, TAT-DPP-TAT, was prepared by several common synthetic methods. On the one hand, the common near infrared organic semiconductor fluorescent materials have good photothermal effect, so the material TAT-DPP-TAT is used for photothermal therapy; on the other hand, Since pyrrolidine pyrrolidone has a good role in photodynamic therapy, it has been tested in photodynamic therapy, and finally the multi-application of materials has been realized.) in this chapter, the structure of traditional fluoropyrrole dipyrrole materials has been changed by means of changing the structure of traditional fluoropyrrole dipyrrole materials. A material with strong fluorescence properties in solid state was designed and synthesized. Several carbazole derivatives were synthesized by Cadogan closed loop design, and then some heat-activated delayed fluorescence materials with donor-receptor structure were synthesized by one-step reaction. Through the study of its performance, including the relationship between its performance and structure, it has been applied in organic electroluminescent devices.
【学位授予单位】：南京邮电大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TB34

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