磁性温敏性碳球的制备及表征
发布时间：2018-07-24 14:29
【摘要】：碳球具有独特的结构和优良的物化性能，能够应用于吸附材料、催化剂载体、电极材料以及药物输送等领域。通过功能化CSs后，引入一些特殊物质，使其具有某些特殊的性能，如磁学、电学和光学等，来拓展碳球的应用范围。本文将磁性和温敏性材料引入碳球，使其成为具有磁和温度双重响应的复合材料，预计其在生物医学、靶向药物控释等领域具有潜在的应用价值。 本论文以葡萄糖、葡萄糖酸亚铁和十六烷基三甲基溴化铵（CTAB）为原料，采用水热法制得磁性碳球（MCSs）。然后以混酸氧化MCSs，，在其表面引入羟基；再通过羟基与硅烷偶联剂KH-570反应，从而在MCSs表面引入双键。在此基础上，通过引发剂、交联剂的作用，将温敏聚合物聚N-异丙基丙烯酰胺（PNIPAM）接枝到MCSs表面，形成包覆层。采用场发射扫描电子显微镜、红外光谱仪、热重分析仪、差示扫描量热法和振动磁强计等手段对产物进行表征和分析。结果如下： 1、懫用绿色源料葡萄糖为碳源，与其结构相似的葡萄糖酸亚铁为铁源，利用条件温和的水热反应体系制备粒径均匀，形貌规整，表面富含含氧官能团并具有一定磁性的碳球MCSs。考察了葡萄糖酸亚铁、CTAB的用量、葡萄糖溶液的浓度、反应时间和反应温度对产物形貌、结构的影响，并探讨了MCSs的形成机理。得到了MCSs的最佳制备条件：葡萄糖溶液浓度0.1mol/L，葡萄糖酸亚铁质量为0.1g、CTAB质量为0.4g、反应温度170℃、反应时间12h。 2、在氧化和硅烷化MCSs的基础上，以NIPAM为温敏单体、KPS为引发剂、MBA为交联剂，在MCSs表面成功地接枝了温敏性聚合物。考察了单体、引发剂和交联剂用量对接枝、形貌和性能的影响。得到最佳接枝聚合反应条件：每0.2g硅烷化的MCSs中加入0.6g NIPAM，引发剂KPS质量为单体的1%，交联剂MBA为单体的15%。分析结果表明所得产物具有磁性和温敏性。 3、以制备的PNIPAM-MCSs为载体，进行阿司匹林药物负载与缓释实验。缓释实验结果表明，随着时间的推迟，药物的释放增加并最终达到平衡。由于高于LCST温度时温敏性聚合物壳收缩使得45℃累积释放的量比25℃高。
[Abstract]:Carbon spheres have unique structure and excellent physical and chemical properties, and can be used in adsorption materials, catalyst carriers, electrode materials and drug transportation. After functionalization of CSs, some special materials are introduced to make them have some special properties, such as magnetism, electricity and optics, to expand the application of carbon spheres. In this paper, magnetic and temperature sensitive materials are introduced into carbon spheres to become composites with both magnetic and temperature responses, which are expected to have potential applications in biomedicine, targeted drug controlled release and so on. In this paper, magnetic carbon ball (MCSs). Was prepared by hydrothermal method using glucose, ferrous gluconate and cetyltrimethylammonium bromide (CTAB) as raw materials. Then the hydroxyl group was introduced on the surface of MCSs by mixed acid oxidation, and then the double bond was introduced on the surface of MCSs by the reaction of hydroxyl group with silane coupling agent KH-570. On this basis, the thermo-sensitive polymer poly (N-isopropylacrylamide) (PNIPAM) was grafted onto the surface of MCSs by the action of initiator and crosslinking agent to form a coating layer. The products were characterized and analyzed by means of field emission scanning electron microscope, infrared spectrometer, thermogravimetric analyzer, differential scanning calorimetry and vibratory magnetometer. The results are as follows: 1. Using green source glucose as carbon source and ferrous gluconate with similar structure as Tie Yuan, the particle size is uniform and the morphology is regular by using the hydrothermal reaction system with mild conditions. The surface is rich in oxygen functional groups and has a magnetic carbon ball MCSs. The effects of the amount of ferrous gluconate CTAB, the concentration of glucose solution, reaction time and reaction temperature on the morphology and structure of the product were investigated. The formation mechanism of MCSs was also discussed. The optimum preparation conditions of MCSs were obtained as follows: the concentration of glucose solution was 0.1 mol / L, the mass of ferrous gluconate was 0.4 g, the reaction temperature was 170 鈩
本文编号：2141671
[Abstract]:Carbon spheres have unique structure and excellent physical and chemical properties, and can be used in adsorption materials, catalyst carriers, electrode materials and drug transportation. After functionalization of CSs, some special materials are introduced to make them have some special properties, such as magnetism, electricity and optics, to expand the application of carbon spheres. In this paper, magnetic and temperature sensitive materials are introduced into carbon spheres to become composites with both magnetic and temperature responses, which are expected to have potential applications in biomedicine, targeted drug controlled release and so on. In this paper, magnetic carbon ball (MCSs). Was prepared by hydrothermal method using glucose, ferrous gluconate and cetyltrimethylammonium bromide (CTAB) as raw materials. Then the hydroxyl group was introduced on the surface of MCSs by mixed acid oxidation, and then the double bond was introduced on the surface of MCSs by the reaction of hydroxyl group with silane coupling agent KH-570. On this basis, the thermo-sensitive polymer poly (N-isopropylacrylamide) (PNIPAM) was grafted onto the surface of MCSs by the action of initiator and crosslinking agent to form a coating layer. The products were characterized and analyzed by means of field emission scanning electron microscope, infrared spectrometer, thermogravimetric analyzer, differential scanning calorimetry and vibratory magnetometer. The results are as follows: 1. Using green source glucose as carbon source and ferrous gluconate with similar structure as Tie Yuan, the particle size is uniform and the morphology is regular by using the hydrothermal reaction system with mild conditions. The surface is rich in oxygen functional groups and has a magnetic carbon ball MCSs. The effects of the amount of ferrous gluconate CTAB, the concentration of glucose solution, reaction time and reaction temperature on the morphology and structure of the product were investigated. The formation mechanism of MCSs was also discussed. The optimum preparation conditions of MCSs were obtained as follows: the concentration of glucose solution was 0.1 mol / L, the mass of ferrous gluconate was 0.4 g, the reaction temperature was 170 鈩
本文编号：2141671
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