生物活性碳纳米纤维增强树脂复合材料的研制
发布时间：2018-08-13 17:26
【摘要】：随着社会经济的发展,交通伤、高处坠落等高能量损伤日益增加,粉碎骨折也随之增多。为使骨折完善愈合和良好功能恢复,需利用骨科修复器件对其进行完善的复位和固定。传统金属材料和单一高分子材料骨科器件各有不足,发展具有高强度、模量适中、应力遮挡作用小、生物相容性的聚合物基复合材料骨修复和固定材料,有利于骨愈合及重塑,如纤维或无机填料等增强的热塑性或热固性复合材料等,成为骨植入材料领域的研究热点。本文采用负载磷酸钙(CaP)纳米粒子短切碳纳米纤维(CNF)对环氧树脂和丙烯酸酯树脂进行增强增韧,考察材料生物学性能,研制了一种新型骨科修复用生物纳米复合材料。首先,结合溶胶凝胶、静电纺丝和原位烧结的技术方法制备了表面和内部负载丰富的磷酸钙纳米粒子的碳纳米纤维(CNF/CaP),通过对溶胶浓度、纺丝工艺和烧结条件的优化,成功制备了纤维直径分布集中、纳米粒子分布均匀的碳纳米纤维,磷酸钙纳米粒子的主要成分为p-磷酸三钙(β-TCP)和羟基磷灰石(HA),在碳纤维上的负载量达到大于10wt%。其次,利用高功率超声剪切技术将连续的CNF/CaP剪切成为离散的短切纤维,其长度分布集中,通过调整超声参数,可对超声后短切纤维的长度分布进行一定程度的控制。由于其纳米粒子主要负载在纤维内部,在物理条件处理下具有极强的纳米粒子保有率,经过500W高功率超声40min后仍能够保留80%的纳米粒子。最后,将短切的生物活性碳纳米纤维与环氧树脂或丙烯酸酯树脂进行复合,获得新型骨修复用生物纳米复合材料。其中磷酸钙纳米粒子负载的碳纳米纤维起到增强增韧作用,并提供一定的钙离子释放,改善材料的生物活性和骨引导性。本文所研制的短切生物活性碳纳米纤维增强环氧树脂复合材料,其弯曲强度可达160MPa,弯曲模量可达6GPa,与人体皮质骨的力学性能相近,能够满足作为接骨板材料的要求。综上所述,负载磷酸钙纳米粒子的短切碳纳米纤维可作为骨修复树脂复合材料的填料,具有增强增韧、生物相容性好、一定生物活性的优点,有望成为新一代骨科修复器件用生物纳米复合材料。
[Abstract]:With the development of social economy, traffic injuries, high energy injuries such as falling from high places are increasing, and comminuted fractures are also increasing. In order to improve fracture healing and functional recovery, orthopaedic repair devices should be used to complete the reduction and fixation. Traditional metal materials and single polymer materials have shortcomings in orthopedic devices, such as high strength, moderate modulus, little stress shielding, biocompatibility polymer matrix composite bone repair and fixation materials, which are conducive to bone healing and remodeling. Reinforced thermoplastic or thermosetting composites, such as fiber or inorganic filler, have become the research focus in bone implant field. In this paper, epoxy resin and acrylate resin were strengthened and toughened by short cut carbon nanofiber (CNF) loaded with calcium phosphate (CaP) nanoparticles. The biological properties of the composites were investigated and a new biological nanocomposite for orthopedic repair was developed. Firstly, carbon nanofibers (CNF/CaP) loaded with rich calcium phosphate nanoparticles were prepared by sol-gel, electrospinning and in-situ sintering. The concentration of sol, spinning process and sintering conditions were optimized. Carbon nanofibers with concentrated fiber diameter distribution and uniform distribution of nanoparticles were successfully prepared. The main components of calcium phosphate nanoparticles were 尾 -TCP and hydroxyapatite (HA), loaded on carbon fiber for more than 10 wts. Secondly, continuous CNF/CaP shearing is transformed into discrete short cut fiber by high power ultrasonic shear technique, and its length distribution is concentrated. By adjusting ultrasonic parameters, the length distribution of short cut fiber after ultrasonic can be controlled to a certain extent. Because the nanoparticles are mainly loaded inside the fiber and have a strong retention rate under physical conditions, 80% nanoparticles can still be retained after 500W high power ultrasonic 40min. Finally, a novel biological nanocomposite for bone repair was obtained by compounding the short cut biological activated carbon nanofibers with epoxy resin or acrylate resin. Among them, the carbon nanofibers supported by calcium phosphate nanoparticles can enhance the toughness, provide certain calcium ion release, and improve the biological activity and bone guidance of the materials. The short cut biological activated carbon nanofiber reinforced epoxy resin composite has a flexural strength of 160 MPA and a flexural modulus of 6 GPA, which is similar to the mechanical properties of human cortical bone and can meet the requirements of bone plate material. In conclusion, short cut carbon nanofibers loaded with calcium phosphate nanoparticles can be used as fillers for bone repair resin composites, with the advantages of enhanced toughness, good biocompatibility and certain biological activity. It is expected to be a new generation of biomaterials for orthopaedic repair devices.
【学位授予单位】：北京化工大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：TB332
本文编号：2181676
[Abstract]:With the development of social economy, traffic injuries, high energy injuries such as falling from high places are increasing, and comminuted fractures are also increasing. In order to improve fracture healing and functional recovery, orthopaedic repair devices should be used to complete the reduction and fixation. Traditional metal materials and single polymer materials have shortcomings in orthopedic devices, such as high strength, moderate modulus, little stress shielding, biocompatibility polymer matrix composite bone repair and fixation materials, which are conducive to bone healing and remodeling. Reinforced thermoplastic or thermosetting composites, such as fiber or inorganic filler, have become the research focus in bone implant field. In this paper, epoxy resin and acrylate resin were strengthened and toughened by short cut carbon nanofiber (CNF) loaded with calcium phosphate (CaP) nanoparticles. The biological properties of the composites were investigated and a new biological nanocomposite for orthopedic repair was developed. Firstly, carbon nanofibers (CNF/CaP) loaded with rich calcium phosphate nanoparticles were prepared by sol-gel, electrospinning and in-situ sintering. The concentration of sol, spinning process and sintering conditions were optimized. Carbon nanofibers with concentrated fiber diameter distribution and uniform distribution of nanoparticles were successfully prepared. The main components of calcium phosphate nanoparticles were 尾 -TCP and hydroxyapatite (HA), loaded on carbon fiber for more than 10 wts. Secondly, continuous CNF/CaP shearing is transformed into discrete short cut fiber by high power ultrasonic shear technique, and its length distribution is concentrated. By adjusting ultrasonic parameters, the length distribution of short cut fiber after ultrasonic can be controlled to a certain extent. Because the nanoparticles are mainly loaded inside the fiber and have a strong retention rate under physical conditions, 80% nanoparticles can still be retained after 500W high power ultrasonic 40min. Finally, a novel biological nanocomposite for bone repair was obtained by compounding the short cut biological activated carbon nanofibers with epoxy resin or acrylate resin. Among them, the carbon nanofibers supported by calcium phosphate nanoparticles can enhance the toughness, provide certain calcium ion release, and improve the biological activity and bone guidance of the materials. The short cut biological activated carbon nanofiber reinforced epoxy resin composite has a flexural strength of 160 MPA and a flexural modulus of 6 GPA, which is similar to the mechanical properties of human cortical bone and can meet the requirements of bone plate material. In conclusion, short cut carbon nanofibers loaded with calcium phosphate nanoparticles can be used as fillers for bone repair resin composites, with the advantages of enhanced toughness, good biocompatibility and certain biological activity. It is expected to be a new generation of biomaterials for orthopaedic repair devices.
【学位授予单位】：北京化工大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：TB332
【参考文献】
相关期刊论文 前1条
1 沈烈;乔飞;张宇强;张稚燕;彭懋;朱飞燕;;炭纤维增强羟基磷灰石/聚乳酸复合生物材料的力学性能和体外降解性能[J];复合材料学报;2007年05期
，本文编号：2181676
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