磁性纳米铜粒子的合成及其在有机合成中的应用
发布时间：2018-09-07 07:45
【摘要】：在过去的数十年中,催化剂已经引起相当多的关注,在制药和精细化工产业有很重要的的应用。催化剂已经应用于许多合成反应。然而,大多数的均相催化剂由于许多实际因素是不适合在工业领域中应用。例如,均相催化剂不易从反应混合物中的简单的分离和重复使用,这是有机合成中的成本控制的有效的方法。在制药业中,它也必须除去所有金属残留痕迹,这经常会干扰随后的反应而污染最终产物。因此,发展一种可回收,重复使用的催化剂是十分必要的。我们制备了新型磁性纳米催化剂Cu Fe O2,用柠檬酸-DMU低熔点混合物作为绿色溶剂。以苯甲醛、2-氨基吡啶和苯乙炔为原料合成咪唑并[1,2-а]吡啶类衍生物,并且得到不错的产率。催化体系可以成功重复使用6次保持其催化活性。我们制备了纳米材料负载铜[Ni Fe2O4-GM-Cu]催化剂,这种催化剂对于合成各种1,4-二取代-1,2,3-三唑表现出优异的催化活性。反应由叠氮化钠、非活化的末端炔烃和不同的叠氮化物前体,如环氧化物、苄基氯和芳基硼酸在水中室温下进行。这种方法有许多突出优势,水作为反应媒介、广泛的底物范围和催化剂可以使用外加磁体进行有效的分离回收。3-硝基-2-苯基咪唑并[1,2-a]吡啶是一类重要的杂环化合物,这类化合物具有广泛的生物活性。我们首先制备了一种磁性纳米材料[Co Fe2O4@CNT-Cu]作为催化剂,在PEG400中以硝基甲烷、2-氨基吡啶和苯甲醛为原料得到相应的3-硝基-2-苯基咪唑并[1,2-a]吡啶类化合物,产率较高。磁性纳米材料对于催化合成3-硝基-2-苯基咪唑并[1,2-a]吡啶类化合物具有较高的催化活性,并且磁性纳米材料的诸多优点如:制备简单、便于与产物分离和可循环利用等,都使得磁性纳米材料的广泛应用于有机合成中成为可能。
[Abstract]:In the past decades, catalysts have attracted considerable attention and have important applications in pharmaceutical and fine chemical industries. Catalysts have been used in many synthetic reactions. However, most homogeneous catalysts are not suitable for industrial application due to many practical factors. For example, homogeneous catalysts are not easy to separate and reuse from the reaction mixture, which is an effective method of cost control in organic synthesis. In the pharmaceutical industry, it must also remove all traces of metal, which often interfere with subsequent reactions and contaminate the end product. Therefore, the development of a recyclable, reusable catalyst is very necessary. A new magnetic nanometer catalyst Cu Fe O 2 was prepared. The citric acid-DMU low melting point mixture was used as green solvent. Imidazo [1] pyridine derivatives were synthesized from benzaldehyde 2-aminopyridine and phenylacetylene, and a good yield was obtained. The catalytic system can be successfully reused for 6 times to maintain its catalytic activity. Nanomaterials supported on copper [Ni Fe2O4-GM-Cu] catalysts have been prepared. The catalysts exhibit excellent catalytic activity for the synthesis of various 1o 4- disubstituted -1o 2o 3- triazole. The reaction was carried out by sodium azide, non-activated terminal alkynes and different azide precursors, such as epoxides, benzyl chloride and aryl boric acid in water at room temperature. This method has many outstanding advantages. Water as a reaction medium, a wide range of substrates and catalysts can be used for effective separation and recovery of .3-nitro-2-phenylimidazo [1o2-a] pyridine as a class of important heterocyclic compounds. These compounds have a wide range of biological activities. In this paper, we first prepared a magnetic nano-material [Co Fe2O4@CNT-Cu] as catalyst, using nitromethane 2-aminopyridine and benzaldehyde as raw materials to obtain the corresponding 3-nitro-2-phenylimidazo [1o 2-a] pyridine compounds in high yield. Magnetic nanomaterials have high catalytic activity for the catalytic synthesis of 3-nitro-2-phenylimidazo [1t2-a] pyridine compounds. The magnetic nanomaterials have many advantages, such as simple preparation, easy separation and recycling, etc. All of these make it possible for magnetic nanomaterials to be widely used in organic synthesis.
【学位授予单位】：河北师范大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：O626.32;TB383.1
[Abstract]:In the past decades, catalysts have attracted considerable attention and have important applications in pharmaceutical and fine chemical industries. Catalysts have been used in many synthetic reactions. However, most homogeneous catalysts are not suitable for industrial application due to many practical factors. For example, homogeneous catalysts are not easy to separate and reuse from the reaction mixture, which is an effective method of cost control in organic synthesis. In the pharmaceutical industry, it must also remove all traces of metal, which often interfere with subsequent reactions and contaminate the end product. Therefore, the development of a recyclable, reusable catalyst is very necessary. A new magnetic nanometer catalyst Cu Fe O 2 was prepared. The citric acid-DMU low melting point mixture was used as green solvent. Imidazo [1] pyridine derivatives were synthesized from benzaldehyde 2-aminopyridine and phenylacetylene, and a good yield was obtained. The catalytic system can be successfully reused for 6 times to maintain its catalytic activity. Nanomaterials supported on copper [Ni Fe2O4-GM-Cu] catalysts have been prepared. The catalysts exhibit excellent catalytic activity for the synthesis of various 1o 4- disubstituted -1o 2o 3- triazole. The reaction was carried out by sodium azide, non-activated terminal alkynes and different azide precursors, such as epoxides, benzyl chloride and aryl boric acid in water at room temperature. This method has many outstanding advantages. Water as a reaction medium, a wide range of substrates and catalysts can be used for effective separation and recovery of .3-nitro-2-phenylimidazo [1o2-a] pyridine as a class of important heterocyclic compounds. These compounds have a wide range of biological activities. In this paper, we first prepared a magnetic nano-material [Co Fe2O4@CNT-Cu] as catalyst, using nitromethane 2-aminopyridine and benzaldehyde as raw materials to obtain the corresponding 3-nitro-2-phenylimidazo [1o 2-a] pyridine compounds in high yield. Magnetic nanomaterials have high catalytic activity for the catalytic synthesis of 3-nitro-2-phenylimidazo [1t2-a] pyridine compounds. The magnetic nanomaterials have many advantages, such as simple preparation, easy separation and recycling, etc. All of these make it possible for magnetic nanomaterials to be widely used in organic synthesis.
【学位授予单位】：河北师范大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：O626.32;TB383.1
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