稀土上转换纳米载体的构建及功能化修饰机制的研究进展
发布时间：2018-09-08 21:05
【摘要】：稀土掺杂的上转换纳米材料可以吸收近红外波长范围的低能量光子而释放出紫外光或可见光波长范围的高能量光子。近年来,由于其独特的光学性能,人们以稀土上转换纳米晶(UCNPs)为基础构建了许多不同的纳米载体,以期能够应用于生物成像、光动力治疗(PDT)、载药系统构建以及生物传感等领域,解决当前癌症诊断和治疗等医学难题。基于UCNPs的纳米载体构建机制种类繁多,根据纳米载体的空间结构及修饰层的位置来归类分析,可将构建机制大体分为三种:UCNPs为核心,修饰层在纳米晶的表面;UCNPs为核,与外壳之间形成中空夹层,修饰层在中空夹层及纳米晶的表面;UCNPs为空心微球的外壳,修饰层在微球的内部及其表面。这三种UCNPs载体构建机制各有利弊。文章将介绍这三种UCNPs载体的构建机制及其相应的表面修饰,总结经过修饰后的功能化纳米载体在不同领域中的应用效果,并对稀土纳米载体构建机制的发展前景进行展望。
[Abstract]:Rare-earth doped up-conversion nanomaterials can absorb low-energy photons in the near infrared wavelength range and release high-energy photons in the ultraviolet or visible wavelength range. In recent years, due to its unique optical properties, many different nano-carriers have been constructed on the basis of rare-earth up-conversion nanocrystalline (UCNPs), which can be used in the fields of bioimaging, photodynamic therapy (PDT), drug carrier system and biosensor. To solve the current medical problems such as cancer diagnosis and treatment. There are many kinds of construction mechanisms of nano-carriers based on UCNPs. According to the spatial structure of nano-carriers and the position of the modified layers, the construction mechanism can be classified into three kinds of UCNPs as the core, and the modified layer is located on the surface of nanocrystals as the core. The modified layer is the outer shell of the hollow microsphere on the surface of the hollow interlayer and nanocrystalline, and the modified layer is inside and on the surface of the microsphere. The construction mechanism of these three UCNPs carriers has its own advantages and disadvantages. This paper will introduce the construction mechanism of the three kinds of UCNPs carriers and the corresponding surface modification, summarize the application effect of the modified functionalized nano-carriers in different fields, and prospect the development prospect of the construction mechanism of rare earth nano-carriers.
【作者单位】： 中国石油大学(华东)重质油国家重点实验室及生物工程与技术中心化学工程学院;青岛大学附属医院;
【基金】：国家自然科学基金项目(21204102) 山东省科技发展计划项目(2014GHY115020) 中央高校基本科研业务费专项资金项目(14CX02190A)资助
【分类号】：TB383.1
本文编号：2231692
[Abstract]:Rare-earth doped up-conversion nanomaterials can absorb low-energy photons in the near infrared wavelength range and release high-energy photons in the ultraviolet or visible wavelength range. In recent years, due to its unique optical properties, many different nano-carriers have been constructed on the basis of rare-earth up-conversion nanocrystalline (UCNPs), which can be used in the fields of bioimaging, photodynamic therapy (PDT), drug carrier system and biosensor. To solve the current medical problems such as cancer diagnosis and treatment. There are many kinds of construction mechanisms of nano-carriers based on UCNPs. According to the spatial structure of nano-carriers and the position of the modified layers, the construction mechanism can be classified into three kinds of UCNPs as the core, and the modified layer is located on the surface of nanocrystals as the core. The modified layer is the outer shell of the hollow microsphere on the surface of the hollow interlayer and nanocrystalline, and the modified layer is inside and on the surface of the microsphere. The construction mechanism of these three UCNPs carriers has its own advantages and disadvantages. This paper will introduce the construction mechanism of the three kinds of UCNPs carriers and the corresponding surface modification, summarize the application effect of the modified functionalized nano-carriers in different fields, and prospect the development prospect of the construction mechanism of rare earth nano-carriers.
【作者单位】： 中国石油大学(华东)重质油国家重点实验室及生物工程与技术中心化学工程学院;青岛大学附属医院;
【基金】：国家自然科学基金项目(21204102) 山东省科技发展计划项目(2014GHY115020) 中央高校基本科研业务费专项资金项目(14CX02190A)资助
【分类号】：TB383.1
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