多孔磁性普鲁士蓝复合材料的合成研究
发布时间：2018-09-08 21:44
【摘要】：介孔磁性普鲁士蓝是很好的纳米医药材料,但目前仍缺少合成这种材料的有效方法,这里我们采用配位复制以及自上而下刻蚀的一锅反应的方法分别以Fe_3O_4为核,得到介孔磁性蛋壳结构Fe_3O_4@PB,不同反应时间的扫描图表明PB晶体在质子作用下在Fe_3O_4表面成核并生长,溶液中多余的质子进一步腐蚀Fe_3O_4及PB得到介孔结构,最后推广此合成方法,以NiFe2O4为核,合成多孔磁性蛋壳结构NiFe2O4@Ni-FePBA。通过在DMF和水的混合溶剂中,配位复制及控制刻蚀的方法合成了多孔核壳Fe_3O_4@片状PB复合材料,并采用同样的方法制备了多孔核壳NiFe2O4@Ni-FePBA复合物,产物均为球形核壳结构,壳层为片状普鲁士蓝类配合物分级结构组装。我们将所合成的介孔蛋壳结构Fe_3O_4@PB磁性复合物应用与多功能纳米医药应用中,介孔蛋壳结构Fe_3O_4@PB可以有效负载药物顺铂,并表现温度敏感释药,对磁场或者红外激光都可以响应释放热量,合成的介孔蛋壳结构Fe_3O_4@PB材料可以有效负载药物并杀死癌细胞。
[Abstract]:The mesoporous magnetic Prussian blue is a good nanometer medical material, but there is still no effective method to synthesize this material. Here we use coordination replication and top-down etching one-pot reaction method to use Fe_3O_4 as the core, respectively. Scanning images of mesoporous magnetic eggshell Fe_3O_4@PB, at different reaction times show that PB crystals nucleate and grow on the surface of Fe_3O_4 under the action of protons, and superfluous protons in solution further corrode Fe_3O_4 and PB to obtain mesoporous structures. Synthesis of porous magnetic eggshell NiFe2O4@Ni-FePBA. with NiFe2O4 as core The porous core-shell Fe_3O_4@ lamellar PB composites were synthesized by coordination replication and etching control in the mixed solvent of DMF and water. The porous core-shell NiFe2O4@Ni-FePBA composites were prepared by the same method. The products were spherical core-shell structure. The shell is composed of flake Prussian blue complexes with hierarchical structure. In the application of the synthesized mesoporous Fe_3O_4@PB magnetic complex and the multifunctional nano-medicine, the mesoporous Fe_3O_4@PB can effectively load the drug cisplatin and exhibit temperature-sensitive drug release. Both the magnetic field and infrared laser can respond to the release of heat. The synthesized mesoporous eggshell Fe_3O_4@PB materials can effectively load drugs and kill cancer cells.
【学位授予单位】：华东师范大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TB33
[Abstract]:The mesoporous magnetic Prussian blue is a good nanometer medical material, but there is still no effective method to synthesize this material. Here we use coordination replication and top-down etching one-pot reaction method to use Fe_3O_4 as the core, respectively. Scanning images of mesoporous magnetic eggshell Fe_3O_4@PB, at different reaction times show that PB crystals nucleate and grow on the surface of Fe_3O_4 under the action of protons, and superfluous protons in solution further corrode Fe_3O_4 and PB to obtain mesoporous structures. Synthesis of porous magnetic eggshell NiFe2O4@Ni-FePBA. with NiFe2O4 as core The porous core-shell Fe_3O_4@ lamellar PB composites were synthesized by coordination replication and etching control in the mixed solvent of DMF and water. The porous core-shell NiFe2O4@Ni-FePBA composites were prepared by the same method. The products were spherical core-shell structure. The shell is composed of flake Prussian blue complexes with hierarchical structure. In the application of the synthesized mesoporous Fe_3O_4@PB magnetic complex and the multifunctional nano-medicine, the mesoporous Fe_3O_4@PB can effectively load the drug cisplatin and exhibit temperature-sensitive drug release. Both the magnetic field and infrared laser can respond to the release of heat. The synthesized mesoporous eggshell Fe_3O_4@PB materials can effectively load drugs and kill cancer cells.
【学位授予单位】：华东师范大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TB33
【参考文献】
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1 孙圣男;魏超;朱赞赞;侯仰龙;Subbu S Venkatraman;徐h酱，
本文编号：2231783
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