新型磁性纳米复合材料的合成及其吸附与核磁共振成像性能的研究
发布时间：2018-10-16 22:50
【摘要】：本文主要研究了新型磁性纳米复合材料的合成及其作为吸附剂以及核磁共振造影剂方面的性能研究。主要研究内容及结果如下： 1.首次通过室温液相还原方法合成了新颖的层状结构的Co/Co(OH)2纳米复合物，，并提出了可能在反应中发生的反应机制和形貌发展。对Co/Co(OH)2进行磁性测试，发现其具有铁磁性行为。用刚果红来评价Co/Co(OH)2纳米复合物的吸附性能。实验中我们发现150ppm的刚果红能够在10min内完全被Co/Co(OH)2纳米复合物从水溶液中移除，并且最大吸附量达到2058mg g1，这比之前所有报道过的值都要高。由于具有移除刚果红所需的时间短，合成方法简单、低成本以及零污染的优点，Co/Co(OH)2可作为一种高效吸附剂从废水中移除有机染料。 2.为了探讨表面活性剂对Co/Co(OH)2纳米复合物的成分与形貌的影响，阴离子表面活性剂柠檬酸钠以及十二烷基苯磺酸钠(SDBS)，聚合物表面活性剂聚乙烯吡咯烷酮(PVP)以及阳离子表面活性剂十六烷基三甲基溴化铵(CTAB)分别被应用到实验中。结果表明产物的形貌在某种程度上受到表面活性剂种类的影响。阴离子表面活性剂，像柠檬酸钠和SDBS，有利于产物形成纳米微球。聚合物和阳离子表面活性剂，像PVP和CTAB不能促进新的形貌的形成。此外，通过HRTEM图片证实了最终产物仍为Co/Co(OH)2复合物，从而我们可以推断出表面活性剂对产物的组成是没有任何影响的。 3.利用一种简单有效地溶剂热法合成修饰的Fe3O4纳米粒子(NPs)，并将这些纳米粒子用于小鼠黑色素瘤的体内核磁共振成像。在本实验中，丙三醇由于具有无毒性和高粘性而被用作溶剂和还原剂，从而导致最终获得的Fe3O4NPs具有分散性好和尺寸分布较窄的优点。此外，基于柠檬酸钠，L-天门冬酰胺以及PVP具有无/低毒性、水溶性和生物适应性的优点，这三种物质将作为表面活性剂用来修饰Fe3O4NPs的表面，并且修饰过程是一步完成而非复杂的嫁接方法。另外，最终得到的修饰后的Fe3O4NPs水溶液被证实具有非常好的胶体稳定性，在6个月内液体中都不会出现絮凝物或者沉淀。然后，为了探究修饰后的Fe3O4NPs作为T2造影剂在核磁共振成像方面的生物应用，检测了NPs的T2加权成像和T2弛豫时间。结果表明，柠檬酸钠修饰的Fe3O4NPs的r2弛豫率要高于柠檬酸钠与PVP以及L-天门冬酰胺修饰的Fe3O4NPs。而且，对修饰后的NPs进行了体内试验，用于检测植入小鼠内的黑色素瘤。
[Abstract]:In this paper, the synthesis of new magnetic nanocomposites and their properties as adsorbent and nuclear magnetic resonance contrast agent were studied. The main contents and results are as follows: 1. Novel layered Co/Co (OH) _ 2 nanocomposites were synthesized by liquid reduction at room temperature for the first time, and the possible reaction mechanism and morphology development were proposed. The magnetic properties of Co/Co (OH) 2 were tested and found to be ferromagnetic. Congo red was used to evaluate the adsorption properties of Co/Co (OH) 2 nanocomposites. In our experiments, we found that the Congo red of 150ppm can be completely removed from the aqueous solution by Co/Co (OH) _ 2 nanocomposites in 10min, and the maximum adsorption capacity is up to 2058mg g _ 1, which is higher than all the previously reported values. Because of its advantages of short time to remove Congo red, simple synthesis method, low cost and zero pollution, Co/Co (OH) _ 2 can be used as an efficient adsorbent to remove organic dyes from wastewater. In order to investigate the effect of surfactants on the composition and morphology of Co/Co (OH) _ 2 nanocomposites, Anionic surfactant sodium citrate, sodium dodecyl benzene sulfonate (SDBS),) polymer surfactant polyvinylpyrrolidone (PVP) and cationic surfactant cetyltrimethylammonium bromide (CTAB) have been applied to the experiment. The results show that the morphology of the product is influenced to some extent by the type of surfactants. Anionic surfactants, such as sodium citrate and SDBS, facilitate the formation of nanospheres. Polymers and cationic surfactants, such as PVP and CTAB, do not promote the formation of new morphologies. In addition, the final product was confirmed to be Co/Co (OH) _ 2 complex by HRTEM images, so we can infer that the surfactant has no effect on the composition of the product. The modified Fe3O4 nanoparticles (NPs), were synthesized by a simple and effective solvothermal method and used in the in vivo nuclear magnetic resonance imaging of murine melanoma. In this experiment, propanetriol was used as solvent and reductant because of its nontoxicity and high viscosity, which led to the advantages of good dispersion and narrow size distribution of Fe3O4NPs. In addition, based on the advantages of sodium citrate, L-asparagine and PVP, which are non-toxic, water-soluble and bioadaptive, these three substances will be used as surfactants to modify the surface of Fe3O4NPs. And the modification process is a step-by-step rather than a complex grafting method. In addition, the final modified Fe3O4NPs aqueous solution was proved to have very good colloidal stability, no flocculation or precipitation occurred in the liquid for 6 months. Then, in order to explore the biological application of modified Fe3O4NPs as a T 2 contrast medium in MRI, the T 2 weighted imaging and T 2 relaxation time of NPs were measured. The results showed that the r2 relaxation rate of sodium citrate modified Fe3O4NPs was higher than that of sodium citrate and PVP and L-asparagine modified Fe3O4NPs.. Furthermore, the modified NPs was tested in vivo to detect melanoma implanted in mice.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：TB383.1;TB33
[Abstract]:In this paper, the synthesis of new magnetic nanocomposites and their properties as adsorbent and nuclear magnetic resonance contrast agent were studied. The main contents and results are as follows: 1. Novel layered Co/Co (OH) _ 2 nanocomposites were synthesized by liquid reduction at room temperature for the first time, and the possible reaction mechanism and morphology development were proposed. The magnetic properties of Co/Co (OH) 2 were tested and found to be ferromagnetic. Congo red was used to evaluate the adsorption properties of Co/Co (OH) 2 nanocomposites. In our experiments, we found that the Congo red of 150ppm can be completely removed from the aqueous solution by Co/Co (OH) _ 2 nanocomposites in 10min, and the maximum adsorption capacity is up to 2058mg g _ 1, which is higher than all the previously reported values. Because of its advantages of short time to remove Congo red, simple synthesis method, low cost and zero pollution, Co/Co (OH) _ 2 can be used as an efficient adsorbent to remove organic dyes from wastewater. In order to investigate the effect of surfactants on the composition and morphology of Co/Co (OH) _ 2 nanocomposites, Anionic surfactant sodium citrate, sodium dodecyl benzene sulfonate (SDBS),) polymer surfactant polyvinylpyrrolidone (PVP) and cationic surfactant cetyltrimethylammonium bromide (CTAB) have been applied to the experiment. The results show that the morphology of the product is influenced to some extent by the type of surfactants. Anionic surfactants, such as sodium citrate and SDBS, facilitate the formation of nanospheres. Polymers and cationic surfactants, such as PVP and CTAB, do not promote the formation of new morphologies. In addition, the final product was confirmed to be Co/Co (OH) _ 2 complex by HRTEM images, so we can infer that the surfactant has no effect on the composition of the product. The modified Fe3O4 nanoparticles (NPs), were synthesized by a simple and effective solvothermal method and used in the in vivo nuclear magnetic resonance imaging of murine melanoma. In this experiment, propanetriol was used as solvent and reductant because of its nontoxicity and high viscosity, which led to the advantages of good dispersion and narrow size distribution of Fe3O4NPs. In addition, based on the advantages of sodium citrate, L-asparagine and PVP, which are non-toxic, water-soluble and bioadaptive, these three substances will be used as surfactants to modify the surface of Fe3O4NPs. And the modification process is a step-by-step rather than a complex grafting method. In addition, the final modified Fe3O4NPs aqueous solution was proved to have very good colloidal stability, no flocculation or precipitation occurred in the liquid for 6 months. Then, in order to explore the biological application of modified Fe3O4NPs as a T 2 contrast medium in MRI, the T 2 weighted imaging and T 2 relaxation time of NPs were measured. The results showed that the r2 relaxation rate of sodium citrate modified Fe3O4NPs was higher than that of sodium citrate and PVP and L-asparagine modified Fe3O4NPs.. Furthermore, the modified NPs was tested in vivo to detect melanoma implanted in mice.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：TB383.1;TB33
【共引文献】
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