纳米技术在抗脑卒中治疗中的应用进展

发布时间：2019-01-19 13:07

【摘要】：脑卒中是神经科的常见多发病,严重影响人们的正常工作和生活质量,并带来沉重的社会负担。因此,人们在不断寻找、开发治疗脑卒中的药物。但是由于药物的药动学性质的缺陷,如溶解度低、半衰期短及难以透过血脑屏障,造成生物利用度低而限制了其临床应用。因此,研究者试图通过对药物剂型的改善而克服上述的缺陷,以研制出治疗卒中疗效更好的药物。新近发展的纳米医学以及纳米技术在此领域的应用,可望改善上述缺陷,是当今研究的热点。本文从中药成分的纳米化与各类纳米载药体系(包括高分子纳米载药体系、金属纳米载体、纳米纤维以及其他新型纳米载药技术)着手,综述及展望了纳米科技在抗脑卒中治疗中的研究进展,为抗卒中药物的研发提供理论基础。
[Abstract]:Stroke is a common frequent disease in neurology, which seriously affects people's normal work and quality of life, and brings a heavy social burden. As a result, people are constantly looking for drugs to treat stroke. However, its clinical application is limited by its low pharmacokinetic properties, such as low solubility, short half-life and difficulty in passing through the blood-brain barrier. Therefore, the researchers try to overcome these deficiencies by improving the dosage form to develop a more effective drug for stroke. The recent development of nanomedicine and the application of nanotechnology in this field are expected to improve these defects. In this paper, the nanocrystalline composition of traditional Chinese medicine and all kinds of nano-drug delivery systems (including polymer nano-drug delivery system, metal nano-carrier, nano-fiber and other new nano-drug delivery technology) are discussed. The progress of nanotechnology in the treatment of stroke is reviewed and prospected, which provides a theoretical basis for the research and development of antistroke drugs.
【作者单位】：首都医科大学七年制临床医学系;首都医科大学医学实验技术系;首都医科大学药理学系;
【基金】：国家自然科学基金(31570856) 北京市自然科学基金(5152005) 2016年北京市教育委员会科技计划一般项目基金(KM201610025003) 首都医科大学首都医科大学本科学生科研训练项目(7NZDS2015)
【分类号】：R943;TB383.1

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