基于正电荷和光热协同效应的新型半导体聚合物纳米抗菌材料（英文）
发布时间：2021-11-14 06:03
由于抗生素的不当使用和细菌多药耐药的出现,迫切需要开发新的抗菌剂.本文制备了具有光热转换性能的正电荷半导体高分子材料及具有协同抗菌活性的半导体聚合物纳米粒子（SP-PPh3NPs）. SP-PPh3NPs的光热转化效率为43. 8%.带正电荷的SP-PPh3NPs可以附着在细菌上,有助于将热量有效传递给细菌.在热和正电荷的协同作用下,SP-PPh3NPs对革兰氏阴性大肠杆菌（E. coli）和革兰氏阳性金黄色葡萄球菌（S.aureus）均具有抗菌活性,其对二者的体外抑菌率分别为99. 9%和98. 6%.此外,SP-PPh3NPs具有良好的生物相容性,对小鼠的主要器官几乎无副作用.对细菌感染的小鼠皮肤伤口用SP-PPh3NPs治疗12 d后,伤口可以很好地愈合.
【文章来源】：高等学校化学学报. 2020,41(04)北大核心EISCICSCD
【文章页数】：12 页
【文章目录】：
1 Experimental
1.1 Reagents and Instruments
1.2 Syntheses of SP-Br and SP-PPh3
1.3 Preparation of SP-PPh3Nanoparticles
1.4 Photothermal Conversion Efficiency
1.5 Cytotoxicity Assessment
1.6 Determination of Half-maximal Inhibitory Concentration
1.7 In vitro Antibacterial Activity
1.8 Morphological Observation of Bacteria
1.9 Wound Healing Experiment
2 Results and Discussion
2.1 Synthesis and Characterization
2.2 In vitro Antibacterial Test
2.3 In vivo Antibacterial Treatment Evaluation
3 Conclusions
本文编号：3494095
【文章来源】：高等学校化学学报. 2020,41(04)北大核心EISCICSCD
【文章页数】：12 页
【文章目录】：
1 Experimental
1.1 Reagents and Instruments
1.2 Syntheses of SP-Br and SP-PPh3
1.3 Preparation of SP-PPh3Nanoparticles
1.4 Photothermal Conversion Efficiency
1.5 Cytotoxicity Assessment
1.6 Determination of Half-maximal Inhibitory Concentration
1.7 In vitro Antibacterial Activity
1.8 Morphological Observation of Bacteria
1.9 Wound Healing Experiment
2 Results and Discussion
2.1 Synthesis and Characterization
2.2 In vitro Antibacterial Test
2.3 In vivo Antibacterial Treatment Evaluation
3 Conclusions
本文编号：3494095
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