WMS的玻璃药瓶内氧气含量检测及其标定方法改进

发布时间：2018-01-05 12:41

  本文关键词：WMS的玻璃药瓶内氧气含量检测及其标定方法改进　出处：《光谱学与光谱分析》2017年10期 　论文类型：期刊论文

  更多相关文章： 波长调制光谱 二次谐波 半高谱峰面积 氧气浓度

【摘要】：应用激光波长调制光谱(WMS)技术,建立了一种开放光路短光程检测玻璃药瓶内氧气含量的方法。选择氧气分子位于760.885(13 142.58cm-1)的吸收谱线,通过多次调试优化了系统相关参数,给出了实时扣背景及实时谱线校正等数据处理的方法和步骤。采集七种不同氧气含量的玻璃药瓶样本,获取相应的二次谐波信号,分别建立二次谐波峰值、半高谱峰面积与浓度的线性回归方程进行定量预测。实验结果表明,其拟合系数分别为0.996 6和0.997 8,后者相比前者的标定方法提高了0.12%。采用完全交互验证的方法来评价两个模型的预测精度,其预测的均方根误差(RMSEP)分别是0.003 1和0.002 0,后者相比前者降低了37.69%。对浓度是4%的气体样品,比较不同时间的20次测量结果,标准差分别为0.002 2和0.0016,后者相比前者降低了27.3%,同时其测量灵敏度分别为0.198%和0.097%,后者相比前者的灵敏度提高了约51%。证明了该系统及数据处理方法对玻璃药瓶内氧气含量检测是可行的,且利用半高谱峰面积更丰富的幅值信息来反演气体浓度可以降低波峰失真影响,检测精度更高,稳定性更好。
[Abstract]:Application of laser wavelength modulation spectroscopy (WMS) technology, a new method of open path detection of glass bottle with short path oxygen content. Oxygen molecules within the 760.885 (13 142.58cm-1) absorption lines, through repeatedly debugging the system parameters optimization is given in real time and real-time deducting background spectrum correction data the processing method and the acquisition of seven different steps. The oxygen content of glass bottle samples, obtaining two harmonic signal corresponding to the establishment of the two harmonic peak, respectively, semi Pufeng area and high concentration linear regression equation for quantitative prediction. Experimental results show that the fitting coefficients were 0.9966 and 0.9978, compared with the former. The calibration method can improve the prediction accuracy of 0.12%. to evaluate the two methods using full cross validation of the model, the root mean square error of prediction (RMSEP) were 0.0031 and 0.0020, the latter than before The 37.69%. is a gas sample of 4% concentration, 20 measurements in different time, the standard deviation is 0.0022 and 0.0016, compared with the former decreased by 27.3%, while its sensitivity were 0.198% and 0.097%, compared with the former sensitivity increased about 51%. proved the system and data processing method the feasibility of detection of oxygen content in the glass bottle, and the use of high Pufeng area half amplitude information more abundant to retrieve the gas concentration can reduce wave distortion, higher detection accuracy and better stability.

【作者单位】： 中南大学信息科学与工程学院;湖南人文科技学院信息学院;
【基金】：国家自然科学基金重点项目(61533021);国家自然科学基金创新研究群体科学基金项目(61621062);国家自然科学基金项目(61773403) 湖南省教育厅重点项目(17A109)资助
【分类号】：TN249;TQ460.69
【正文快照】： 引　言　　在制药行业中,密封玻璃药瓶内的氧气含量直接决定药品的氧化速度,影响保质期,目前我国除极少数制药企业引进国外先进检测装备在线检测外,其他企业都是采用基于气相色谱原理、电化学原理或磁氧分析等方法和手段进行抽样检测。随着半导体激光器的发展,波长调制光谱(wa，

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