基于压电振荡原理的微阵列点样系统的研制
发布时间：2018-07-16 18:38
【摘要】：针对基于电磁微阀原理的非接触点样方式存在操作过程复杂、点样量偏大,以及压电喷墨原理的非接触点样方式存在点样针不易清洗、造价昂贵等不足,研制了一种基于压电振荡原理的新型非接触点样装置,实现了微量液体点样。在本装置中,毛细管点样针与压电驱动装置为两个独立单元,可以单独对毛细管点样针进行更换和清洗。采用激光拉制法制备的玻璃毛细管点样针具有内径可调、成本低等优点。此点样方式通过改变压电陶瓷的振幅和频率,可在10~(-10)~10~(-9)L之间调控点样体积。以此为基础,结合三维精密位移控制技术,研制了一种基于压电振荡原理的微阵列生物芯片点样系统。对点样系统的点样体积、点样密度、点样精度等参数进行了测试,结果表明,此点样系统的最小点样体积可达320 pL,点样密度可达4000点/cm~2,并能够实现界面图案化制备。
[Abstract]:In this paper, a new non contact sample device based on the principle of piezoelectric oscillation is developed for the non contact point pattern based on the principle of electromagnetic micro valve, such as complicated operation process, large amount of point sample and non contact point pattern of piezoelectric ink-jet principle. In the device, the capillary point needle and the piezoelectric driving device are two independent units, which can be replaced and cleaned separately. The glass capillary point needle prepared by laser drawing has the advantages of adjustable inner diameter and low cost. By changing the amplitude and frequency of the piezoceramic, it can be in 10~ (-10) ~10~ (-9) L. On the basis of this, a microarray biological chip sampling system based on the principle of piezoelectric oscillations is developed on the basis of three dimensional precision displacement control technology. The point sample size, point sample density and point sample precision are tested. The results show that the minimum sample size of the point sample system can reach 320 pL, The sample density can reach 4000 /cm~2, and the interface patterning can be achieved.
【作者单位】： 长春理工大学光电工程学院;中国科学院长春应用化学研究所;
【基金】：中国科学院科研装备研制项目(No.YZ201355)资助
【分类号】：TN492
本文编号：2127285
[Abstract]:In this paper, a new non contact sample device based on the principle of piezoelectric oscillation is developed for the non contact point pattern based on the principle of electromagnetic micro valve, such as complicated operation process, large amount of point sample and non contact point pattern of piezoelectric ink-jet principle. In the device, the capillary point needle and the piezoelectric driving device are two independent units, which can be replaced and cleaned separately. The glass capillary point needle prepared by laser drawing has the advantages of adjustable inner diameter and low cost. By changing the amplitude and frequency of the piezoceramic, it can be in 10~ (-10) ~10~ (-9) L. On the basis of this, a microarray biological chip sampling system based on the principle of piezoelectric oscillations is developed on the basis of three dimensional precision displacement control technology. The point sample size, point sample density and point sample precision are tested. The results show that the minimum sample size of the point sample system can reach 320 pL, The sample density can reach 4000 /cm~2, and the interface patterning can be achieved.
【作者单位】： 长春理工大学光电工程学院;中国科学院长春应用化学研究所;
【基金】：中国科学院科研装备研制项目(No.YZ201355)资助
【分类号】：TN492
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