基于复合液滴的金属比例可控Janus球制备及其电动特性研究
发布时间：2018-09-07 08:00
【摘要】：液滴微流控技术作为一种新兴的流体操控技术,可以实现微纳米级别的液滴生成,并且生成的液滴可以具有多种形式和功能,已然成为生物、化学、医疗、材料等工程应用领域开发新型材料与器件的方法,其涉及应用范围包括单细胞分析、药物筛选、个人洗护等。Janus型粒子作为一种双极性粒子具有良好的两亲性,不同结构的Janus粒子可以具有多种功能,在药物运输、复合材料、MEMS器件等方面具有广泛的应用价值。传统的Janus粒子的制备过程复杂,需用的仪器多,材料的利用率不高。利用液滴微流控的方式进行Janus粒子的合成精简了粒子制备的过程,提高了材料的利用率,同时实现了不同比例Janus粒子的合成。液滴微流控芯片是一个研究平台,其目的是为各领域的应用提供方法。根据液滴的结构以及功能的不同需求,需要设计不同结构的液滴微流控芯片。针对Janus复合液滴,本文设计一种利用θ型玻璃毛细管一步生成Janus复合液滴的玻璃毛细管微流控芯片结构,根据此结构对金属比例不同的Janus复合液滴制备做了以下研究。根据微通道内两相流的基本理论与液滴形成过程中的受力分析,推导了液滴大小与各相流体流速的关系式,建立了基于共轴流法的液滴生成仿真模型,对影响液滴生成大小及频率的关键因素,如流体流速、表面张力进行了模拟分析,为生成液滴的玻璃微流控芯片的设计提供支撑。根据理论分析和仿真模拟设计,搭建了“一步”生成Janus复合液滴的实验平台,分析了连续相及分散相流速对液滴大小、尺寸均匀性及生成频率的影响;研究了Janus复合液滴中金属所占比例与两分散相流速的关系,实现了金属比例可控的Janus复合液滴高效合成,以Janus复合液滴为结构诱导剂,固化生成了金属比例可控的Janus微球。根据非均匀电场中介电泳力对粒子的操控原理,分析了Janus微球在非均匀电场中非对称极化现象、受到的负介电泳力与频率响应特性及电旋转现象,进而对Janus微球在电场中的运动情况进行了合理的分析。
[Abstract]:The droplet microfluidic technology, as a new fluid manipulation technology, can realize droplet formation at the micro and nanometer level, and the droplet generated can have many forms and functions, and has become biological, chemical and medical. Methods for developing new materials and devices in engineering applications such as materials, including single-cell analysis, drug screening, personal washing and protection, and so on. Janus particles have good amphiphilic properties as a kind of bipolar particles. Janus particles with different structures can have a variety of functions and have a wide range of applications in the fields of drug transport, composite materials, Janus devices and so on. The preparation process of traditional Janus particles is complicated, many instruments are needed, and the utilization ratio of materials is not high. The synthesis of Janus particles by droplet microfluidic method simplifies the process of particle preparation, improves the utilization ratio of materials, and realizes the synthesis of different proportions of Janus particles at the same time. Droplet microfluidic chip is a research platform, which aims to provide methods for applications in various fields. According to the different requirements of droplet structure and function, droplet microfluidic chips with different structures need to be designed. A glass capillary microfluidic chip based on 胃 type glass capillary to produce Janus composite droplets is designed for Janus composite droplets. According to this structure, the preparation of Janus composite droplets with different metal ratios is studied as follows. According to the basic theory of two-phase flow in microchannel and the analysis of force during the formation of droplets, the relationship between droplet size and flow velocity of each phase is derived, and the simulation model of droplet generation based on coaxial flow method is established. The key factors affecting the size and frequency of droplet formation, such as fluid velocity and surface tension, are simulated and analyzed, which provides support for the design of glass microfluidic chip for droplet formation. Based on the theoretical analysis and simulation design, a "one-step" experimental platform for generating Janus composite droplets was built, and the effects of flow rate of continuous phase and dispersed phase on droplet size, size uniformity and generation frequency were analyzed. The relationship between the proportion of metal in Janus composite droplets and the flow rate of two dispersed phases was studied. The high efficiency synthesis of Janus composite droplets with controllable metal ratio was realized. Janus microspheres with controllable metal ratio were prepared by solidifying Janus composite droplets as structural inducers. According to the control principle of particles by the intermediate electrophoretic force of non-uniform electric field, the asymmetric polarization phenomenon of Janus microspheres in non-uniform electric field, the negative dielectric electrophoresis force and frequency response, and the electric rotation phenomenon are analyzed. Then the motion of Janus microspheres in electric field is analyzed reasonably.
【学位授予单位】：哈尔滨工业大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TN492;O359
本文编号：2227677
[Abstract]:The droplet microfluidic technology, as a new fluid manipulation technology, can realize droplet formation at the micro and nanometer level, and the droplet generated can have many forms and functions, and has become biological, chemical and medical. Methods for developing new materials and devices in engineering applications such as materials, including single-cell analysis, drug screening, personal washing and protection, and so on. Janus particles have good amphiphilic properties as a kind of bipolar particles. Janus particles with different structures can have a variety of functions and have a wide range of applications in the fields of drug transport, composite materials, Janus devices and so on. The preparation process of traditional Janus particles is complicated, many instruments are needed, and the utilization ratio of materials is not high. The synthesis of Janus particles by droplet microfluidic method simplifies the process of particle preparation, improves the utilization ratio of materials, and realizes the synthesis of different proportions of Janus particles at the same time. Droplet microfluidic chip is a research platform, which aims to provide methods for applications in various fields. According to the different requirements of droplet structure and function, droplet microfluidic chips with different structures need to be designed. A glass capillary microfluidic chip based on 胃 type glass capillary to produce Janus composite droplets is designed for Janus composite droplets. According to this structure, the preparation of Janus composite droplets with different metal ratios is studied as follows. According to the basic theory of two-phase flow in microchannel and the analysis of force during the formation of droplets, the relationship between droplet size and flow velocity of each phase is derived, and the simulation model of droplet generation based on coaxial flow method is established. The key factors affecting the size and frequency of droplet formation, such as fluid velocity and surface tension, are simulated and analyzed, which provides support for the design of glass microfluidic chip for droplet formation. Based on the theoretical analysis and simulation design, a "one-step" experimental platform for generating Janus composite droplets was built, and the effects of flow rate of continuous phase and dispersed phase on droplet size, size uniformity and generation frequency were analyzed. The relationship between the proportion of metal in Janus composite droplets and the flow rate of two dispersed phases was studied. The high efficiency synthesis of Janus composite droplets with controllable metal ratio was realized. Janus microspheres with controllable metal ratio were prepared by solidifying Janus composite droplets as structural inducers. According to the control principle of particles by the intermediate electrophoretic force of non-uniform electric field, the asymmetric polarization phenomenon of Janus microspheres in non-uniform electric field, the negative dielectric electrophoresis force and frequency response, and the electric rotation phenomenon are analyzed. Then the motion of Janus microspheres in electric field is analyzed reasonably.
【学位授予单位】：哈尔滨工业大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TN492;O359
【参考文献】
相关期刊论文 前1条
1 陈晓东;胡国庆;;微流控器件中的多相流动[J];力学进展;2015年00期
相关博士学位论文 前1条
1 吴平;液滴微流控的实验应用和理论研究[D];中国科学技术大学;2014年
相关硕士学位论文 前2条
1 于帅;微流控中液滴的形成与操纵机理及其实验研究[D];哈尔滨工业大学;2013年
2 崔馨;分离压作用下表面活性剂溶液的铺展特性研究[D];华北电力大学;2011年
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