基于PDMS的集成式压电驱动微流体反应器的设计与实验研究

发布时间：2018-07-03 21:29

本文选题：微反应器 + 压电微泵　；参考：《吉林大学》2015年硕士论文

【摘要】：本文提出一种基于PDMS的集成式压电驱动微流体反应器，它将压电微泵、微混合流道、微反应流道集成在同一块PDMS基片上，利用该反应器可实现多种主动混合模式，克服了目前主动微流体反应器存在的不足，提高了微尺度下流体的混合效果和速率，充分发挥了主动式微流体反应器混合高效的特点。它是一种主动性更强、过程可控的新型主动式微流体反应器，特别是在贵金属纳米粒子(比如金、银、铂等)的合成方面具有更大的优势。具体研究内容如下：分析探究了将压电微泵集成在微流体反应器芯片上的可行性，利用制作微流体反应器芯片的工艺和材料（PDMS）制作了微泵泵体，并对完成整机装配后的压电微泵进行了工作性能测试，实验证实自制基于PDMS的压电微泵具有良好的工作性能，，其不仅能够输送像水这样粘度比较低的液体，对于粘度较高的流体（如氯金酸等化学反应溶液）也有较好的输送性能。对微反应器的微混合流道进行了Fluent流体仿真分析计算，并将其仿真计算结果输出数据文件和工程文件，工程文件导入Tecplot进行后处理得到混合流道组分浓度分布图，数据文件导入MATLAB进行混合度值的计算，以综合评价不同参数条件下的混合效果，优选出了最佳结构参数和工作参数，以对微反应器的制作和后期实验参数的设定提供依据。根据优选出的微流道结构参数和压电微泵输出性能对微反应器各芯片进行了集成化结构设计，在传统微流控芯片制作工艺的基础上研究并设计了其制作工艺，最后制得整机尺寸为40mm×40mm×4mm的微反应器各芯片（双腔微泵驱动下微混合芯片的为50mm×50mm×6mm），做到了微反应器的集成化、微型化、便携化。用本文作者自制的微流体反应器进行了金纳米粒子的液相合成实验，验证了自制微流体反应器的工作性能，证明了其在贵金属纳米粒子可控合成等复杂化学反应中的应用优势。实验证明调节压电微泵的入口流量和工作频率会对金纳米粒子的大小、形貌产生影响，证明了本文自制微流体反应器在可控合成金纳米粒子方面的可行性及优势。调节微泵电压为20V、30V、40V，工作频率为100Hz、200Hz、300Hz，可合成粒径范围大致从20nm到70nm之间的球状、类球状的金纳米粒子。实验证明：除了微泵工作参数外的其他因素（如是否加入CTAB、还原剂柠檬酸钠的浓度等）也会对所合成的金纳米粒子的形貌产生影响，所以下一步需要对溶液酸碱度、温度等微泵工作参数外的影响因素进行实验探究，以得出其最佳匹配值，从而更好的利用本文自制的微流体反应器进行纳米粒子的可控‖合成。
[Abstract]:In this paper, an integrated piezoelectric driven micro fluid reactor based on PDMS is proposed. It integrates piezoelectric micropump, micro mixing channel and micro reaction channel on the same PDMS substrate. It overcomes the shortcomings of active microfluid reactor at present, improves the mixing effect and rate of micro-fluid in micro-scale, and gives full play to the characteristics of active micro-fluid reactor mixing efficiency. It is a new type of active microfluid reactor with more initiative and controllable process, especially in the synthesis of noble metal nanoparticles (such as gold, silver, platinum, etc.). The specific research contents are as follows: the feasibility of integrating piezoelectric micropump into microfluidic reactor chip is analyzed, and the micropump body is made by using the technology and material (PDMS) of microfluidic reactor chip. The experimental results show that the self-made piezoelectric micropump based on PDMS not only can transport liquid with lower viscosity as water, but also has good performance. For high viscosity fluids (such as chloro-gold acid and other chemical reaction solutions) also has a better transport performance. The fluent fluid simulation analysis was carried out on the micro mixing channel of the microreactor, and the simulation results were output data file and engineering file, and the engineering files were imported into Tecplot for post-processing to obtain the mixture flow channel component concentration distribution diagram. The data file was imported into MATLAB to calculate the mixing degree value, to evaluate the mixing effect under different parameters, and to select the best structure parameters and working parameters, so as to provide the basis for the fabrication of microreactor and the setting of later experiment parameters. Based on the optimized structure parameters of microchannel and the output performance of piezoelectric micropump, the integrated structure of microreactor chips is designed. Based on the traditional microfluidic chip fabrication technology, the fabrication process is studied and designed. Finally, the microreactor chips with the size of 40mm 脳 40mm 脳 4mm (50mm 脳 50mm 脳 6mm) driven by dual-chamber micropump are fabricated. The microreactor is integrated, miniaturized and portable. In this paper, the liquid phase synthesis experiments of gold nanoparticles were carried out in a self-made microfluid reactor. The performance of the self-made micro-fluid reactor was verified, and the advantages of its application in complex chemical reactions such as controllable synthesis of noble metal nanoparticles were proved. It is proved that adjusting the inlet flow rate and working frequency of piezoelectric micropump will affect the size and morphology of gold nanoparticles. The feasibility and advantage of the self-made micro-fluid reactor in the controllable synthesis of gold nanoparticles are proved. The micropump voltage is 20V ~ 30V ~ (-1) 40 V and the working frequency is 100Hz ~ 200Hz ~ (300) Hz. The spherical, globular gold nanoparticles with particle size ranging from 20nm to 70nm can be synthesized. The experimental results show that other factors, such as the addition of CTAB, the concentration of sodium citrate and so on, will also affect the morphology of the gold nanoparticles, so the next step is to determine the pH of the solution. In order to obtain the best matching value, the factors that affect the working parameters of micropump such as temperature are investigated in order to make better use of the micro-fluid reactor made in this paper for the synthesis of nano-particles.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：TQ052

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