金属—有机骨架材料作为手性选择剂的高分子膜研究

发布时间：2018-11-23 19:35

【摘要】：手性是一个普遍的自然现象。一些对映体具有独特的生物活性,分离纯的对映体对药物的安全性极其重要。膜分离技术因其成本低,节能,易于连续操作和规模化,成为优于其它分离外消旋混合物的分离技术。手性MOFs-高分子混合膜因其高孔隙率和低的传介阻力,具备较高的对映选择性。本论文主要研究手性MOFs-高分子混合膜对D,L-对羟基苯甘氨酸和D,L-甲硫氨酸的分离应用。论文主要工作:1)合成[Zn_2Camph_2(dabco)]·DMF·H_2O、[Zn_2Camph_2bpe]·5DMF·H_2O以及[Mg(L-tart)(H_2O)]?1.5H_2O三个手性MOFs晶体,依次制备成手性色谱柱用作拆分D,L-对羟基苯甘氨酸和D,L-甲硫氨酸研究。实验结果表明,手性色谱柱A和B对D,L-对羟基苯甘氨酸有较好的拆分效果;手性色谱柱C对D,L-甲硫氨酸有一定的拆分效果,其为拆分D,L-对羟基苯甘氨酸和D,L-甲硫氨酸提供了新的手性分离材料。2)以醋酸纤维素为基质膜,手性MOFs材料[Zn_2Camph_2(dabco)]·DMF·H_2O为手性识别剂制备醋酸纤维素膜混合膜,对D,L-对羟基苯甘氨酸进行了分离研究。实验结果表明,以浓度差、压力差为驱动力,该膜对D,L-对羟基苯甘氨酸有一定的拆分效果。一些影响手性分离操作效果的参数在该研究中进行了一定程度的研究。3)以纤维素为基质膜,金属-有机骨架材料[Zn_2Camph_2bpe]·5DMF·H_2O晶体为手性识别剂制备纤维素混合膜,对D,L-对羟基苯甘氨酸进行了分离研究。实验结果表明,以浓度差、压力差为驱动力,该膜对L-对羟基苯甘氨酸有20%~50%过剩值。4)以醋酸纤维素为基质膜,金属-有机骨架材料[Mg(L-tart)(H_2O)]?1.5H_2O晶体为手性识别剂制备醋酸纤维素膜混合膜,对D,L-甲硫氨酸进行了分离研究。实验结果表明,以浓度差、压力差为驱动力,该膜对D,L-甲硫氨酸有一定的拆分能力,但D,L-甲硫氨酸在该混合膜的透过性较低。
[Abstract]:Chirality is a universal natural phenomenon. Some enantiomers have unique biological activity, and the separation of pure enantiomers is very important for the safety of drugs. Because of its low cost, energy saving, easy continuous operation and large scale, membrane separation technology is superior to other separation technologies for racemic mixtures. Chiral MOFs- polymer mixed membranes have high enantioselectivity due to their high porosity and low transmission resistance. In this paper, the application of chiral MOFs- polymer mixed membrane to the separation of DL- p-hydroxyphenylglycine and DL- methionine was studied. The main work of this paper is as follows: 1) three chiral MOFs crystals [Zn_2Camph_2 (dabco)] DMF H _ 2O, [Zn_2Camph_2bpe] 5DMF H _ 2O and [Mg (L-tart) (H _ 2O)]? 1.5H_2O are synthesized. Chiral chromatographic columns were prepared in turn for the resolution of DL- p-hydroxyphenylglycine and DL- methionine. The experimental results show that the chiral columns A and B have a good resolution effect on DL- p-hydroxyphenylglycine. The chiral column C has a certain resolution effect on DL- methionine, which provides a new chiral separation material for the resolution of DL- p-hydroxyphenylglycine and DL- methionine. 2) the cellulose acetate is used as the matrix membrane. The chiral MOFs material [Zn_2Camph_2 (dabco)] DMF H _ 2O was used as chiral recognition agent to prepare cellulose acetate membrane mixed membrane. The experimental results show that the film has a certain resolution effect on DL- p-hydroxyphenylglycine with different concentration and pressure difference as the driving force. Some parameters affecting chiral separation were studied to some extent in this study. 3) Cellulose was used as substrate membrane. Cellulose mixed membrane was prepared by [Zn_2Camph_2bpe] 5DMF H _ 2O crystal as chiral recognition agent. The separation of p-hydroxyphenylglycine (p-hydroxyphenylglycine) was studied. The experimental results showed that the membrane had a 50% excess value for L- p-hydroxyphenylglycine with concentration difference and pressure difference as driving force. 4) cellulose acetate was used as substrate membrane. Mg (L-tart) (H _ 2O)? 1.5H_2O crystal was used as chiral recognition agent to prepare cellulose acetate membrane mixed membrane. The separation of DL-methionine was studied. The experimental results show that the DL-methionine film has a certain resolution ability with the driving force of different concentration and pressure difference, but the transmissivity of DL- methionine in the mixed membrane is low.
【学位授予单位】：云南师范大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TQ051.893

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