Gemini阳离子型表面活性剂作用下羟基磷灰石的合成及其性能的研究
发布时间：2018-12-15 08:21
【摘要】：羟基磷灰石是脊椎动物的牙齿和骨骼的主要成分,良好的生物相容性,高度的成骨潜能性,可以通过骨传导机制促进新骨的生长而不会产生任何局部或全身的炎症反应,也可以作为模板化合物,用于研究人体中的生物矿化。HAp粒子还可以抑制多种癌细胞的生长,是作为生物医学应用的首选材料。通过控制HAp晶体的形貌、尺寸和粒径分布,可以扩大它的潜在应用。本论文以Ca(NO_3)_2·4H_2O和(NH_4)_3PO_4·3H_2O为原料,以Gemini阳离子型表面活性剂为模板,采用生物矿化法和水热法,通过改变不同的实验条件制备出具有特殊形貌的HAp。选取不同比表面积和孔径的HAp样品为载体,以万古霉素为模型,通过改变药物负载条件,研究药物的负载性能和缓释能力。采用X射线衍射仪(XRD)、傅立叶变换红外光谱(FT-IR)、扫描电镜(SEM)、热重分析(TG)分别对产物的晶相结构、组成、晶体形貌、热学性能进行分析,并分析了不同形貌的HAp晶体形成的机理。实验表明,Gemini阳离子表面活性剂的浓度对HAp形貌产生影响,有机模板的极性基团和HAp晶体间的相互作用能够影响HAp的成核和生长。用紫外可见分光光度计(UV)测定样品的吸光度,分析药物的负载能力和缓释性能。实验表明在37 ℃的负载温度下,载药时间为24h时,HAp的比表面积越大,万古霉素的负载浓度越大,更有利于药物的负载。最佳负载条件下,药物负载容量为78.95%,药物负载量为44.12 mg/g,包封率为58.83%,累积释放率为84%。
[Abstract]:Hydroxyapatite is a major component of the teeth and bones of vertebrates, with good biocompatibility, high osteogenic potential, and the ability to promote the growth of new bones through bone conduction without any local or systemic inflammatory response. HAp particles can also inhibit the growth of many kinds of cancer cells and are the preferred materials for biomedical applications. The potential application of HAp crystal can be expanded by controlling its morphology, size and particle size distribution. In this paper, Ca (NO_3) _ 2 4H_2O and (NH_4) _ 3PO_4 3H_2O were used as raw materials and Gemini cationic surfactant as template. HAp. with special morphology was prepared by changing different experimental conditions. HAp samples with different specific surface area and pore size were selected as carriers, vancomycin was used as model, and the loading performance and sustained release ability of vancomycin were studied by changing drug loading conditions. X-ray diffraction (XRD) (XRD), Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscope (SEM),) thermogravimetric analysis (TG) were used to analyze the crystal phase structure, composition, crystal morphology and thermal properties of the products, respectively. The formation mechanism of HAp crystals with different morphologies was analyzed. The experimental results show that the concentration of Gemini cationic surfactants affects the morphology of HAp, and the interaction between the polar groups of organic templates and HAp crystals can affect the nucleation and growth of HAp. The absorbance of the sample was determined by UV-vis spectrophotometer (UV), and the drug loading capacity and slow-release property were analyzed. The experimental results show that the larger the specific surface area of HAp is, the greater the loading concentration of vancomycin is, and the better the loading time is when the loading temperature is 37 鈩，
本文编号：2380333
[Abstract]:Hydroxyapatite is a major component of the teeth and bones of vertebrates, with good biocompatibility, high osteogenic potential, and the ability to promote the growth of new bones through bone conduction without any local or systemic inflammatory response. HAp particles can also inhibit the growth of many kinds of cancer cells and are the preferred materials for biomedical applications. The potential application of HAp crystal can be expanded by controlling its morphology, size and particle size distribution. In this paper, Ca (NO_3) _ 2 4H_2O and (NH_4) _ 3PO_4 3H_2O were used as raw materials and Gemini cationic surfactant as template. HAp. with special morphology was prepared by changing different experimental conditions. HAp samples with different specific surface area and pore size were selected as carriers, vancomycin was used as model, and the loading performance and sustained release ability of vancomycin were studied by changing drug loading conditions. X-ray diffraction (XRD) (XRD), Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscope (SEM),) thermogravimetric analysis (TG) were used to analyze the crystal phase structure, composition, crystal morphology and thermal properties of the products, respectively. The formation mechanism of HAp crystals with different morphologies was analyzed. The experimental results show that the concentration of Gemini cationic surfactants affects the morphology of HAp, and the interaction between the polar groups of organic templates and HAp crystals can affect the nucleation and growth of HAp. The absorbance of the sample was determined by UV-vis spectrophotometer (UV), and the drug loading capacity and slow-release property were analyzed. The experimental results show that the larger the specific surface area of HAp is, the greater the loading concentration of vancomycin is, and the better the loading time is when the loading temperature is 37 鈩，
本文编号：2380333
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