镍氢催化的烯烃的还原远程sp~3-C—H键芳基化反应

发布时间：2018-02-23 23:05

  本文关键词： sp~-C—H键 芳基化反应 氢催化 有机化学研究 消除反应 反应模型 区域选择性 官能化 不对称 反应模式 　出处：《有机化学》2017年03期 　论文类型：期刊论文

【摘要】：正J.Am.Chem.Soc.2017,139,1061~1064碳氢键官能团化是有机化学研究的热点,目前的方法大多需要特定的导向基,较高的温度,限制了其实用性.烯烃来源丰富,制备简单.南京大学化学化工学院朱少林课题组利用烯烃和镍氢化学来引发远程sp~3-C—H键官能团化,净结果是双键被无痕地还原而远程C—H键被官能团化.该反应模型巧妙利用镍氢与烯烃发生插入/消除反应诱
[Abstract]:Direct J.Am.Chem.Soc.2017 / 139C 1061N 1064 hydrocarbon bond functionalization is a hot spot in organic chemistry. Most of the current methods require specific guidance groups and higher temperatures, which limit their practicability. The research group of Zhu Shaolin, School of Chemistry and Chemical Engineering, Nanjing University, used olefin and nickel-hydrogen chemistry to initiate the functionalization of remote sp~3-C-H bonds. The net result is that the double bond is reduced without trace and the remote C-H bond is functionalized. This reaction model cleverly utilizes the inducement of insertion / elimination reaction between nickel hydrogen and olefin.
【分类号】：O621.251
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