温敏含糖嵌段共聚物的合成及其胶束的自组装

发布时间：2018-03-07 01:11

  本文选题：温度敏感性　切入点：含糖嵌段共聚物　出处：《功能材料》2016年09期 　论文类型：期刊论文

【摘要】：采用酶促法合成含半乳糖单体6-O-乙烯基壬二酸-D-吡喃型半乳糖酯(OVZG),采用可逆加成-链断裂转移自由基聚合法(RAFT聚合)将大分子引发剂二聚乙二醇单甲醚甲基丙烯酸甲酯(DEGMA)和OVZG有效结合,制备相对分子质量(简称分子量)分散系数(PDI)较低的温敏性含半乳糖嵌段共聚物PDEGMA-b-POVZG。通过核磁共振氢谱(1 H NMR),傅里叶变换红外光谱(FT-IR),凝胶渗透色谱(GPC)对聚合物结构进行了确认表征。通过紫外-可见光谱(UV-Vis)研究表明,共聚物的低临界溶解温度(LCST)可以通过共聚单体的比例进行调控,当PDEGMA与OVZG的物质的量之比为1∶63时,含糖共聚物的LCST值为33℃。在37℃生理温度下,PDEGMA-b-POVZG可以自组装形成纳米胶束,透射电子显微镜(TEM)显示自组装形成的聚合物胶束是结构均匀、形貌规整的球形,通过动态光散射(DLS)测得纳米微球的粒径约为167nm,该温敏性半乳糖嵌段共聚物在药物载体方面具有潜在的应用前景。
[Abstract]:Enzymatic synthesis of 6-O- vinylazelenedioic acid (6-OVZGN) containing galactose monomethyl propene with diethylene glycol monomethyl ether was carried out by reversible addition-chain break transfer radical polymerization (raft polymerization). Methyl ester acid (DEGMA) and OVZG were effectively combined with each other. The temperature sensitive PDEGMA-b-POVZG copolymer containing galactose block copolymer was prepared with low molecular weight dispersion coefficient (PDI). The structure of the polymer was studied by 1H NMR, FTIR, GPC and FT-IR spectra. The effect of PDEGMA-b-POVZG on the structure of the polymer was studied by means of 1H NMR, Fourier transform infrared spectroscopy (FTIR) and gel permeation chromatography (GPC). Confirmed characterization was carried out. UV-Visanalysis by UV-Vis spectra showed that, When the ratio of PDEGMA to OVZG is 1: 63, the LCST value of sugary copolymers is 33 鈩，

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