Polyprenylated acylphloroglucinols from the fruits of Hyperi

发布时间：2018-03-13 04:30

  本文选题：polyprenylated　切入点：acylphloroglucinols　出处：《Science China(Chemistry)》2016年09期 　论文类型：期刊论文

【摘要】：Hyphenrones R X(1 7), seven new polyprenylated acylphloroglucinols derivatives, were isolated from the fruits of Hypericum henryi, together with eight know analogues. Compounds 1 and 2 were elucidated to possess complex caged skeleton, while compounds 3 6 shared a common 3,9-epoxy moiety deriving from the normal polyprenylated acylphloroglucinols with a bicyclo[3.3.1]nonane-2,4,9-trione core. The new structures were elucidated on the basis of the interpretation of nuclear magnetic resonance(NMR) data, circular dichroism(CD) comparison, and single-crystal X-ray diffraction. In the bioassay, several compounds exhibited inhibitory activities against human tumor cell lines in vitro.
[Abstract]:Hyphenrones R X(1 7), seven new polyprenylated acylphloroglucinols derivatives, were isolated from the fruits of Hypericum henryi, together with eight know analogues. Compounds 1 and 2 were elucidated to possess complex caged skeleton, while compounds 3 6 shared a common 3,9-epoxy moiety deriving from the normal polyprenylated acylphloroglucinols with a bicyclo[3.3.1]nonane-2,4,9-trione core. The new structures were elucidated on the basis of the interpretation of nuclear magnetic resonance(NMR) data, circular dichroism(CD) comparison, and single-crystal X-ray diffraction. In the bioassay, several compounds exhibited inhibitory activities against human tumor cell lines in vitro.
【作者单位】： State
【基金】：supported by the Natural Sciences Foundation of Yunnan Province (2015FA032) Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China (P2015-ZZ07) the foundation from Youth Innovation Promotion Association CAS to X.W. Yang and G. Xu the West Light Foundation of the Chinese Academy of Sciences to X.W. Yang
【分类号】：O629;TQ460.1

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