曙红（Eosin Y）催化缩羰基化反应的研究

发布时间：2018-03-13 13:03

本文选题：Eosin　切入点：Y　出处：《合肥工业大学》2016年硕士论文　论文类型：学位论文

【摘要】：缩醛或缩酮化广泛用于多步合成中的醛和酮的羰基保护,缩醛和缩酮是重要的合成中间体和高附加值的化工产品,因而缩羰基化反应一直是人们研究的热点领域。有机分子催化具有温和高效,绿色无污染的特点。然而有机分子催化的缩羰基化反应多采用有机酸或可以产生质子酸的催化剂,它们提供仍然是酸性的反应环境。因此,本论文研究目标是选用一种提供非酸反应环境的有机分子催化剂,实现了温和条件下的缩羰基化反应。本文选择廉价易得的曙红(Eosin Y)作为催化剂,探讨其催化缩羰基化反应的活性和适应性。首先,以甲醇和苯甲醛的缩醛化反应作为模型反应,通过对各个反应影响因素的筛选,确定了最优的反应条件。在此基础之上,论文进行了羰基化合物和醇类化合物的底物拓展,实验结果表明Eosin Y催化的缩羰基化反应具有极强的催化活性和底物适应性,反应的最高产率可达99%。同时本文研究不同底物的反应活性,并分析造成活性差别的原因。最后通过分析总结前人的研究工作和自身的实验结果,本文提出了Eosin Y催化的可能反应机理。
[Abstract]:Acetal or ketal is widely used for protecting the carbonyl groups of multi-step synthesis of aldehydes and ketones, acetal and ketal is an important synthetic intermediate and high value-added chemical products, so the ketalization reaction has been a hot research field. It has a mild and efficient organic molecular catalysis, characteristics of green pollution-free. However the reaction of organic molecules catalyzed acetalization with organic acid or acid catalyst can produce proton, they provide is still acidic reaction environment. Therefore, the goal of this thesis is to provide a selection of non organic acid catalyst reaction environment, realize the ketalization reaction under mild conditions. This choice cheap eosin (Eosin Y) as a catalyst to investigate the catalytic acetalization reaction activity and adaptability. First of all, by acetalization of benzaldehyde and methanol as a model reaction, the reaction The influencing factors of the optimal reaction conditions were determined. On this basis, the thesis of carbonyl compounds and alcohols substrate expansion, the experimental results indicate that the reaction of Eosin Y catalyzed acetalization has strong catalytic activity and substrate specificity, thereactivity of most high yield up to 99%. at the same time on different substrates, and analyzes the causes of the difference of the activities. Finally experimental results of previous research work and the summary through the analysis, the paper puts forward the possible reaction mechanism of Eosin catalyzed by Y.

【学位授予单位】：合肥工业大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：O621.251

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