手性磷-烯配体在不对称催化领域的研究进展

发布时间：2018-03-17 06:26

本文选题：不对称催化　切入点：手性配体　出处：《化学学报》2017年07期 　论文类型：期刊论文

【摘要】：手性磷-烯配体在不对称催化反应中的应用近年来受到化学家们的关注,已经成为一个热门的研究领域.磷-烯配体作为一类新兴杂化烯烃配体,将具有强配位能力的磷原子与配位方式特殊但配位能力相对较弱的碳-碳双键结合在一起,兼具了部分手性膦配体和手性双烯配体的优点,在一些过渡金属如铑、钯、铱等催化的不对称反应中表现出独特的催化性能,不但能高效催化反应,而且能取得优异的对映选择性.本文综述了自2004年首例磷-烯配体的合成及应用报道以来该领域的研究进展,对过去十几年中发展的各种手性磷-烯配体的结构特征、合成方法以及它们在不同催化不对称反应中的应用进行了分类概括,期望为未来进一步拓展手性烯烃配体的类型和应用提供思考和方向.
[Abstract]:In recent years, the application of chiral phospho-ene-ligands in asymmetric catalytic reactions has attracted the attention of chemists and has become a hot research field. As a new class of hybrid olefin ligands, phospho-ene-ligands have become a hot research field. The combination of phosphorus atoms with strong coordination ability with carbon-carbon double bonds with special coordination mode but relatively weak coordination ability has the advantages of some chiral phosphine ligands and chiral diene ligands, in some transition metals such as rhodium and palladium, Iridium and other catalytic asymmetric reactions show unique catalytic performance, not only can be highly efficient catalytic reactions, Moreover, excellent enantioselectivity can be obtained. In this paper, the progress in this field has been reviewed since the first report on the synthesis and application of phosphonene ligands in 2004, and the structural characteristics of various chiral phosphonene ligands developed in the past ten years have been reviewed. The synthesis methods and their applications in different catalytic asymmetric reactions are classified and summarized, which are expected to provide some ideas and directions for the further development of the types and applications of chiral olefin ligands in the future.
【作者单位】：中国科学院上海药物研究所新药研究国家重点实验室;
【基金】：国家自然科学基金(Nos.21325209,21472205) 上海市优秀学术带头人计划(No.14XD1404400)资助~~
【分类号】：O641.4;O643.36

【参考文献】