碘催化合成五元、六元氮杂环化合物

发布时间：2018-03-25 20:41

本文选题：五元、六元氮杂环化合物　切入点：多取代咪唑　出处：《兰州大学》2017年硕士论文

【摘要】：含氮杂环化合物代表着一类具有特殊意义的化合物,而五元、六元氮杂环化合物在其中起着举足轻重的作用。本论文详细概述对多取代咪唑化合物和1,2,4-三嗪化合物合成方法的研究和探讨,主要由以下四部分组成。第一章咪唑化合物在五元氮杂环化合物中扮演着重要角色,拥有的良好生物活性来源于其结构的独特性,在药物化学,材料化学及有机合成化学等领域发挥着关键作用。因而,吸引着大批的化学科研人员对其合成方法及应用的探讨研究。文中我们对前人的工作进行了归纳和总结。第二章1,2,4-三嗪因其独特的结构被人类发现于许多天然和合成的药理活性化合物中。化学研究人员对其应用和合成方法产生了浓厚的兴趣,在此我们对他们的工作进行了详细阐述。第三章I_2/TBPB催化氧化苯乙醛和苯甲脒在溶剂二氧六环中合成1,2,5-三取代咪唑化合物。该方法使用廉价的催化剂,无配体,产率高,产物具有优异的区域选择性。第四章I_2/IBX催化氧化苯乙烯和N-氨基脒在溶剂二甲基亚砜中环加成合成1,2,4-三嗪化合物。整个过程包括三个不同的反应:碘化,Kornblum氧化和缩合。
[Abstract]:Nitrogen-containing heterocyclic compounds represent a class of compounds of special significance, and five-member compounds, In this paper, the synthesis methods of polysubstituted imidazole compounds and 1tandruff 4-triazine compounds are reviewed in detail, which play an important role in the synthesis of hexagonal nitrogen heterocyclic compounds, which play an important role in the synthesis of polysubstituted imidazole compounds. The first chapter is that imidazole compounds play an important role in quaternary nitrogen heterocyclic compounds and have good biological activity due to their unique structure. Materials chemistry and organic synthesis chemistry play a key role. It has attracted a large number of chemical researchers to study its synthetic methods and applications. In this paper, we have summarized and summarized the previous work. Among the synthetic pharmacological active compounds, chemical researchers have shown great interest in their application and synthetic methods. In chapter 3, I_2/TBPB catalyzes the oxidation of phenylacetaldehyde and benzoamidine in the solvent dioxane to synthesize 1o 2n 5- trisubstituted imidazole compounds. This method uses cheap catalyst, no ligand and high yield. In chapter 4, I_2/IBX catalyzes the oxidation of styrene and N-aminamidine in the solvent dimethyl sulfoxide to synthesize 1m2n 4- triazine compound. The whole process includes three different reactions: oxidation and condensation of Kornblum iodide.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：O626

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