葡聚糖水凝胶微球的制备与表征

发布时间：2018-04-03 19:14

  本文选题：葡聚糖　切入点：水凝胶微球　出处：《功能材料》2017年02期

【摘要】：采用反相微乳液交联法,以葡聚糖天然高分子为原料,制备了一系列基于葡聚糖的水凝胶微球。葡聚糖通过高碘酸钠氧化进行醛基化修饰,进一步与乙二胺发生还原胺化反应进行交联;交联反应在以失水山梨酸酯类(Span 80/Tween 80)表面活性剂复配体系作为乳化剂、环己烷为油相构成的油包水型反相微乳液中进行。表面活性剂复配体系的组分配比是影响该葡聚糖水凝胶微球的粒径及形貌的重要因素,研究结果表明,随着表面活性剂复配体系的亲水亲油平衡值(HLB value)增加,微球粒径呈现先减小而后增大并基本保持不变的趋势;当该复配表面活性剂的HLB=5.27(即,m(Tween 80)/m(Span 80)=10)时,获得的葡聚糖凝胶微球粒径最小且平均粒径为(21.6±1.65)μm,粒径分布在15~28μm之间。
[Abstract]:A series of hydrogel microspheres based on dextran were prepared by reverse microemulsion crosslinking method.Dextran was modified by aldehyde by oxidation of sodium periodate, and further crosslinked with ethylenediamine by reductive amination. The crosslinking reaction was carried out in the system of sorbic acid ester Span 80/Tween 80) as emulsifier.Cyclohexane was used in the oil-in-water reverse-phase microemulsion composed of cyclohexane.The composition and distribution ratio of surfactants was an important factor affecting the particle size and morphology of the dextran hydrogel microspheres. The results showed that with the increase of hydrophilic and lipophilic equilibrium (HLB value),寰�鐞冪矑寰勫憟鐜板厛鍑忓皬瑁�

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