拥挤剂粒子形状对大分子链成环动力学的影响

发布时间：2018-04-16 08:36

本文选题：链成环动力学 + 拥挤剂形状　；参考：《中国科学技术大学》2017年硕士论文

【摘要】：利用三维朗之万动力学模拟算法,我们研究了拥挤剂粒子的形状对大分子链成环动力学的影响。我们发现球状拥挤剂粒子情况下的链成环过程主要是由介质粘度的增加主导控制的,因此随着体系中拥挤剂粒子体积分数φ的增加,成环过程将会变得越来越慢。然而与之相反地是,在圆柱状(棒状)拥挤剂中,大分子链成环动力学变得十分的复杂。尤其是在体积分数φ = 0.36-0.44时,我们发现平均成环时间τc有一个戏剧性的下降。随后我们认为这个意料之外τc的戏剧性的下降主要是由于棒状拥挤剂粒子在此体积分数范围时会发生由无序向向列型转变。我们的结果为拥挤的细胞环境中生物大分子的成环过程提供了一个更深入的理解。
[Abstract]:Using the three dimensional Langevin kinetic simulation algorithm, we studied the effect of the shape of the crowding agent particles on the ring dynamics of macromolecular chains.We find that the chain ring formation process in the case of spherical crowding agent particles is mainly controlled by the increase of medium viscosity. Therefore, with the increase of volume fraction 蠁 of crowding agent particles in the system, the ring forming process will become more and more slow.In contrast, in cylindrical (rod) crowding agents, the ring-forming dynamics of macromolecular chains become very complex.Especially when the volume fraction 蠁 = 0.36-0.44, we find that the mean ring-forming time 蟿 _ c has a dramatic decrease.Then we think that the dramatic decline of 蟿 c is mainly due to the transition from disorder to column type in the range of volume fraction of rod-shaped crowding agent particles.Our results provide a deeper understanding of the ring-forming process of biological macromolecules in crowded cellular environments.
【学位授予单位】：中国科学技术大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：O631

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