Ⅱ型糖尿病患者与健康男性血清中19种微量元素含量对比

发布时间：2018-04-29 23:31

本文选题：微量元素 + 糖尿病　；参考：《质谱学报》2017年02期

【摘要】：微量元素代谢在糖尿病患者中可能发生了改变,这些元素在糖尿病发病机制和发展中起特定的作用。本工作研究了年龄区间50~60岁男性Ⅱ型糖尿病患者(95例)与健康人对照组(91例)的血清微量元素含量的差异。采用微波消解法对血清中19种微量元素进行前处理,稀释25倍,选择电感耦合等离子体质谱法(ICP-MS)进行检测。该方法的检测限、精密度和重复性良好,符合血清微量元素的检测要求。相比于对照组,糖尿病患者血清中锰、钴、铜、钡和铅元素的含量相对较高,钒、锌、砷、锑和钨元素的含量相对较低,而铬、铁、镍、硒、钼、镉、锡、汞和铊元素的含量在糖尿病患者和健康对照组中无显著统计学差异。结果表明,与糖尿病密切相关的10种微量元素在年龄区间50~60岁男性糖尿病患者与健康人之间存在显著统计学差异。该结论可为进一步研究与微量元素缺乏或者过量相关的糖尿病发病机制和发展过程提供数据支持。
[Abstract]:Microelement metabolism may change in diabetic patients. These elements play a specific role in the pathogenesis and development of diabetes. In this work, we studied the difference in serum trace elements in the age range 50~60 years old male type 2 diabetes mellitus (95 cases) and the healthy control group (91 cases). The microwave digestion method was used to determine the serum level of 1. 9 kinds of trace elements were pretreated and diluted by 25 times and selected by inductively coupled plasma mass spectrometry (ICP-MS). The detection limit, precision and repeatability of this method were good, which met the requirements of the detection of serum trace elements. Compared with the control group, the content of manganese, cobalt, copper, barium and lead in the serum of diabetic patients was relatively high, vanadium, zinc, and arsenic, The content of antimony and tungsten elements was relatively low, while chromium, iron, nickel, selenium, molybdenum, cadmium, tin, mercury and thallium were not significantly different in diabetic patients and healthy controls. The results showed that there was a significant difference between the 10 trace elements closely related to diabetes in men with diabetes and healthy people in the age range of 50~60 years. Conclusion this conclusion can provide data support for further research on the pathogenesis and development of diabetes mellitus related to deficiency or excess of trace elements.

【作者单位】：天津大学精密仪器与光电子工程学院;Institution
【基金】：国家863计划(2014AA022305,2014AA020901)资助
【分类号】：R587.1;O657.63

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