手性金属—有机骨架材料用作毛细管气相色谱固定相研究

发布时间：2018-04-30 10:59

本文选题：金属-有机骨架材料 + 毛细管柱　；参考：《云南师范大学》2017年硕士论文

【摘要】：手性金属-有机骨架材料是一种多孔材料,存在较多的手性识别位点和热稳定性较好等优点,所以能够作为气相色谱手性固定相。本论文旨在合成手性金属-有机骨架材料,并将这些材料采用动态涂敷的办法制备手性毛细管柱,研究其色谱柱的分离性能。主要研究内容如下:(1)利用二肽的金属-有机骨架材料Co-L-GG作为手性固定相,制备了毛细管色谱柱,并研究拆分性能。实验结果表明位置异构体、混和正构烷烃(正戊烷到正十一烷)、混和醇(丙醇到辛醇)和Grob试剂在该柱子具有较好的分离性能。Co-L-GG作毛细管柱气相色谱柱表现很好的手性识别性能,30种不同种类的化合物得到不同程度的拆分。实验结果证明我们制作的Co-L-GG毛细管柱比之前的金属-有机骨架毛细管柱具有更好的手性识别能力,所以具有更好的应用前景。(2)合成金属-有机骨架材料Co(Gly-Asp),采用动态涂覆的方法制备Co(Gly-Asp)毛细管柱,并考察分离性能。实验证明该柱对正构烷烃、混合醇、位置异构体和Grob试剂具有较好的分离效果,最重要的是Co(Gly-Asp)毛细管柱对手性物具有较好的拆分效果。(3)制备Ni(s-mal)bipy毛细管柱气相色谱柱。考察了该柱的手性识别能力,实验结果表明Ni(s-mal)bipy对6种手性样品具有一定的手性识别能力,对9种位置异构体也具有较好的分离性能,对正构烷烃混合物、正构醇混合物和Grob试剂也具有较好的分离效果。实验结果证明制作的Ni(s-mal)bipy毛细管柱也有较好的应用前景。(4)制备Co(s-nip)毛细管气相色谱柱,并研究该柱的色谱分离性能,实验证明8种手性化合物在Co(s-nip)毛细管上表现较好的分离能力。除此之外,位置异构体、正构烷烃混合物、正构醇混合物和Grob试剂也具有较好的分离效果。实验结果证明制作的Co(s-nip)毛细管柱具有一定的应用前景。
[Abstract]:Chiral metal-organic skeleton is a porous material with many chiral recognition sites and good thermal stability, so it can be used as a chiral stationary phase in gas chromatography. In this paper, chiral metal-organic skeleton materials were synthesized, and the chiral capillary column was prepared by dynamic coating. The main contents are as follows: (1) Capillary column was prepared by using dipeptide metal-organic skeleton material Co-L-GG as chiral stationary phase and its resolution performance was studied. The experimental results show that the position isomers, Mixed n-alkanes (n-pentane to n-undecane), mixed alcohols (propanol to octanol) and Grob reagent have good separation performance on this column. Classes of compounds are separated to varying degrees. The experimental results show that the Co-L-GG capillary column has better chiral recognition ability than the previous metal-organic skeleton capillary column. Therefore, it has a better application prospect. It can be used to synthesize metal-organic skeleton material (Co-Gly-Aspp). Co-Gly-Aspp capillary column is prepared by dynamic coating method, and its separation performance is also investigated. The results show that the column has good separation efficiency for n-alkanes, mixed alcohols, position isomers and Grob reagents. The most important thing is that the Ni(s-mal)bipy capillary column chiral compounds have a better resolution effect. 3) the Ni(s-mal)bipy capillary column gas chromatographic column is prepared. The chiral recognition ability of the column was investigated. The experimental results show that Ni(s-mal)bipy has certain chiral recognition ability for 6 chiral samples, good separation for 9 position isomers, and good separation for n-alkane mixtures. The mixture of normal alcohols and Grob reagent also has good separation effect. The experimental results show that the prepared Ni(s-mal)bipy capillary column also has a good prospect of application in the preparation of Co-nip-capillary gas chromatographic column. The chromatographic separation performance of the column has been studied. The experimental results show that the eight chiral compounds have good separation ability on the Co-nip-capillary column. In addition, position isomers, n-alkane mixtures, n-alcohols and Grob reagents also have good separation effects. The experimental results show that the prepared Cos-nip-capillary column has a certain application prospect.
【学位授予单位】：云南师范大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：O657.71

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