质谱法在药物立体异构体区分中的应用及发展

发布时间：2018-05-05 04:05

  本文选题：手性分子 + 质谱法　； 参考：《质谱学报》2017年04期

【摘要】：质谱法广泛应用于化学、生命科学、药学等领域,能够提供分子质量信息,有助于未知物结构的解析,具有分辨率高、信息量大、样品用量少、灵敏快速等优点,在测定有机化合物精确分子质量、结构解析、反应机理等方面发挥着重要的作用。手性药物是药学领域的一个研究热点,近年来质谱法逐渐被用于药物手性杂质区分中,而且随着质谱技术的不断发展和改进,其在手性区分和分析中越来越受关注。本工作主要介绍了质谱法在手性药物立体异构体杂质分析中的应用及发展历程,阐述了各类质谱技术用于手性异构体分析的原理和特点,其中详细举例介绍了质谱动力学方法和离子淌度质谱方法在手性杂质分析中的应用。通过对比分析目前已有的各类手性分析方法的优缺点,说明利用质谱法实现手性异构体的区分和定量测定具有明显的优势。质谱法用于药物手性异构体的分离具有快速、不需要复杂的样品前处理和昂贵的手性柱等特点,极大地提高了手性药物分析的效率和准确度。随着质谱分析技术的迅速发展,质谱法将在多手性中心药物的手性杂质分离和生物大分子分析(如多糖、多肽)等领域发挥巨大潜能。
[Abstract]:Mass spectrometry is widely used in the fields of chemistry, life science, pharmacy and so on. It can provide molecular mass information and help to analyze the structure of unknown objects. It has the advantages of high resolution, large amount of information, small amount of sample, quick sensitivity, and so on. It plays an important role in the determination of molecular weight, structure resolution and reaction mechanism of organic compounds. Chiral drugs are a hot research topic in pharmaceutical field. In recent years, mass spectrometry has been used to distinguish chiral impurities. With the development and improvement of mass spectrometry technology, chiral separation and analysis have attracted more and more attention. In this paper, the application and development of mass spectrometry in the analysis of chiral drug stereoisomers are introduced, and the principles and characteristics of various mass spectrometry techniques for the analysis of chiral isomers are described. The application of mass spectrometry kinetic method and ion mobility mass spectrometry in chiral impurity analysis is described in detail. By comparing and analyzing the advantages and disadvantages of all kinds of existing chiral analysis methods, it is shown that the use of mass spectrometry to distinguish and determine chiral isomers has obvious advantages. The separation of drug chiral isomers by mass spectrometry has the advantages of fast separation, no complicated sample pretreatment and expensive chiral column, which greatly improves the efficiency and accuracy of chiral drug analysis. With the rapid development of mass spectrometry, mass spectrometry will exert great potential in the field of chiral impurity separation and biomolecules analysis (such as polysaccharides, polypeptides) of multi-chiral center drugs.
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本文编号：1846102