纸喷雾敞开式质谱法的发展和应用

发布时间：2018-05-05 10:22

本文选题：敞开式质谱法 + 电喷雾电离　；参考：《化学进展》2017年06期

【摘要】：纸喷雾质谱法是一种新型的敞开式质谱技术,其以低价易处理的纸为载体,将样品加在三角形的纸上,通过施加高电压,目标分子在电场的驱动下到达纸尖,瞬间气化形成电喷雾,样品离子化后进入质谱进行分析。它具有敞开式质谱法和电喷雾电离技术的特点,可以在开放式大气压环境下对样品或样品表面的物质进行分析,分析成本低、高通量、简便、实时、快速,可简化工作流程,提高质谱仪器的易用性。本文从纸喷雾质谱法的原理出发,介绍了影响其电离效率的主要因素(如载体基质,溶剂系统,洗脱方式等),并对近几年该技术的改进和发展,及其在生物样品检测、植物化学分析、品种鉴别、食品安全和环境分析等领域的应用进行了综述,全面介绍了该项技术的特点和优势。多项研究证明纸喷雾质谱法是一个应用面广泛,具有很大发展前景的分析技术,对其开展研究工作十分有意义。最后讨论了纸喷雾质谱法存在的不足,并提出了相关改进的设想。
[Abstract]:Paper-spray mass spectrometry is a new open mass spectrometry technology. The sample is added to triangular paper on the carrier of low price and easy to deal with. By applying high voltage, the target molecule can reach the tip of the paper under the driving of electric field. The sample was ionized and then analyzed by mass spectrometry. It has the characteristics of open mass spectrometry and electrospray ionization technology. It can be used to analyze samples or materials on the surface of samples under open atmospheric pressure. It has the advantages of low cost, high throughput, simplicity, real-time, rapidity, and can simplify the work flow. Improve the ease of use of mass spectrometer. Based on the principle of paper-ionization mass spectrometry, the main factors affecting the ionization efficiency (such as carrier matrix, solvent system, elution method, etc.) are introduced in this paper. The improvement and development of this technique in recent years and its detection in biological samples are also discussed. The applications of phytochemical analysis, variety identification, food safety and environmental analysis were reviewed, and the characteristics and advantages of this technique were introduced. Many studies have proved that paper-spray mass spectrometry is an analytical technique with wide application and great development prospect, and it is of great significance to carry out research work. Finally, the shortcomings of paper spray-mass spectrometry are discussed, and some suggestions for improvement are put forward.
【作者单位】：湖南师范大学植化单体开发与利用湖南省重点实验室;湖南师范大学化学生物学及中药分析教育部重点实验室;南华大学化学化工学院;
【基金】：国家自然科学基金项目(No.21575040,21405044,21275049) 湖南省自然科学基金项目(No.2015JC1001)资助~~
【分类号】：O657.63

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