基于功能化的金纳米的共振瑞利散射方法手性识别肉碱对映体（英文）

发布时间：2018-05-16 06:35

本文选题：功能化的金纳米粒子 + 肉碱对映体　；参考：《光谱学与光谱分析》2017年06期

【摘要】：一种不经分离而同时测定手性对映体的简便方案是非常有趣和有用的。提出一种基于共振瑞利散射(RRS)光谱技术手性识别新方法,利用功能化的金纳米粒子(Au NPs)同时检测肉碱对映体。AuNPs的RRS强度很弱,但当Cu~(2+)存在时,RRS强度显著增加。更有趣的是,肉碱对映体均可以降低Cu~(2+)-Au NPs体系的RRS强度,但D-肉碱使RRS降低更多。在最优实验条件下,均有良好的线性关系并有很好的相关系数以及较低的检出限。由此,这种方法可以计算出肉碱对映体的对映体比率和对映体分数。并应用于胶囊样品中肉碱对映体混合物手性识别的研究。该方法不需要复杂的手性修饰处理,并具有简捷低消耗、灵敏度高、选择性好等优点。
[Abstract]:A simple scheme for simultaneous determination of chiral enantiomers without separation is very interesting and useful. A novel chiral recognition method based on resonance Rayleigh scattering spectroscopy (RRS) is proposed. The RRS intensity of carnitine enantiomer. AuNPs is detected by functionalized gold nanoparticles (au NPs) at the same time. However, the RRS intensity of carnitine enantiomers increases significantly when Cu~(2 is present. More interestingly, carnitine enantiomers can decrease the RRS strength of Cu~(2 NPs system, but D-carnitine reduces RRS more. Under the optimal experimental conditions, there is a good linear relationship, a good correlation coefficient and a low detection limit. The enantiomeric ratio and enantiomeric fraction of carnitine enantiomers can be calculated by this method. It was applied to the chiral recognition of carnitine enantiomers in capsules. This method does not require complex chiral modification, and has the advantages of simple and low consumption, high sensitivity and good selectivity.
【作者单位】：三峡库区水环境演变与污染防治重庆市高校市级重点实验室环境与化学工程学院重庆三峡学院;
【基金】：the National Science Foundation of China(21175015,21475014)
【分类号】：O614.123;TB383.1

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